Royalty Report: Medical, Device, Diagnostic – Collection: 6023

$150.00

Curated Royalty Rate Report
Category: Technology Licenses, Created On: 2022-04-28, Record Count: 20

Description

This collection of transactions and supporting information was developed using our AI algorithm to curate similar royalty reports into a cohesive collection to support your licensing, transfer pricing or other transaction scenarios where documented royalty rates and/or deal terms are important.
Category: Technology Licenses
Created On: 2022-04-28
Record Count: 20

Primary Industries

  • Medical
  • Device
  • Diagnostic
  • Scientific & Technical Instruments
  • Cancer
  • Dental
  • Test/Monitoring
  • Laser
  • Semiconductors
  • Fabrication
  • Electrical & Electronics
  • Software
  • Medical Info
  • Content
  • Genome
  • Personal Care Products
  • Surgical
  • Computers & Office Equipment
  • Consumer Electronics
  • Security
  • Therapeutic

IPSCIO Report Record List

Below you will find the records curated into this collection.  This summary includes the complete licensed property description so that you can review and determine if this collection covers the topics, technology or transaction type that is relevant for your needs.  The full report will include all relevant deal data such as the royalty base, agreement date, term description, royalty rates and other deal terms.  For reference, here is a sample of a full IPSCIO curated royalty rate report: Sample Report

IPSCIO Record ID: 6023

License Grant
The Licensor has granted the Licensee a non-exclusive worldwide license to use certain medical imaging technologies, known as Optical Coherence Tomography, or ‘OCT,’ in the field of general dentistry, excluding oral surgery and imaging through a microscope.
License Property
(a) Licensee’s Release of a Licensed Product;
(b) Licensee’s First Commercial Sale of a Licensed Product; or
(c) the second anniversary of the effective date.

Optical Coherence Tomography is a technique for obtaining sub-surface images of translucent or opaque materials at a resolution equivalent to a low-power microscope. It is effectively ‘optical ultrasound’, imaging reflections from within tissue to provide cross-sectional images.

There are many industrial, medical, and other applications where high resolution (generally less than 10 micrometer) images of, and measurements of distances, thicknesses, and optical properties of, a biological or other sample are required.

“Method And Apparatus For Optical Imaging With Means For Controlling The Longitudinal Range Of The Sample”  Issued US Patent 5,321,501, June 14, 1994. Filed 4/29/92. – A method and apparatus for performing optical imaging on a sample wherein longitudinal scanning or positioning in the sample is provided by either varying relative optical path lengths for an optical path leading to the sample and to a reference reflector, or by varying an optical characteristic of the output from an optical source applied to the apparatus. Transverse scanning in one or two dimensions is provided on the sample by providing controlled relative movement between the sample and a probe module in such direction and/or by steering optical radiation in the probe module to a selected transverse position. The probe module may be an external module or may be an endoscope or angioscope utilized for scanning internal channels. Multiple optical paths may be provided for parallel scanning and focus may be enhanced by varying the focal point in the sample in synchronism with longitudinal scanning of the sample.

“Method and Apparatus for Performing Optical Measurements” Issued US Patent 5,459,570, Oct. 14, 1995. Filed 3/16/93.

“Method and Apparatus for Performing Optical Imaging and Measurements” Issued in Europe and Japan.

“Method and Apparatus for Acquiring Images using a CCD Detector Array and No Transverse Scanner” Issued US Patent 5,465,147, Nov. 7, 1995. Filed 6/2/94. CIP of 4/29/91 filing.

“Method and Apparatus for Performing Optical Measurements using a Fiber Optic Imaging Guidewire, Catheter or Endoscope” Issued US Patent 6,134,003, Oct. 17, 2000. Filed 2/27/96.

“Methods and Apparatus for Forward-Directed Optical Scanning Instruments for the Acquisition of Optical Imaging and Delivery of Optical Radiation,” Pending Patent.

“Grating Based Phase Control Optical Delay Line” Issued US Patent 6,111,645 August, 2000.

“Method and Apparatus for Performing Optical Measurements using a Rapidly Frequency Tuned Laser” Issued US Patent 5,956,355 September 21, 1999.

“Short Coherence Length, Doppler Velocimetry System” Issued US Patent 5,501,226, 3/26/96. Filed 10/16/94. Issued EPO and Japan.

“Short Coherence Length, Doppler Velocimetry System” Issued US Patent 5,549,114, 8/27/96. Filed 10/23/95. Issued EPO and Japan.

“Optical Coherence Tomography Assisted Surgical Apparatus” Issued US Patent 6,004,314 December 21, 1999.

“OCT-Assisted Surgical Microscope with Multi- Coordinate Manipulator” Issued US Patent 5,795,295.

“Optical Coherence Tomography with New Interferometer” Issued US Patent 6,053,613.

“Method and Apparatus for Simultaneous Measuring the Length and Refractive Error of and Eye” Issued US Patent 5,975,699.

Measurement of Lens Characteristics” Issued US Patent 5,469,261 11/21/95.

“Fundus Illumination Apparatus Formed from Three Separated Radiation Path Systems” Issued US Patent 5,506,634, 4/9/96.

“Optical Coherence Tomography Corneal Mapping Apparatus” Issued US Patent 5,491,524, 2/13/96. Filed 10/5/94.

“Method and Apparatus for Optical Coherence Tomographic Fundus Imaging” Pending Patent.

“Gaze Tracking using Optical Coherence Tomography” Issued US Patent 5,644,642, 7/1/97. Filed 4/3/95.

“Optical Coherence Tomography Assisted Ophthalmologic Surgical Microscope” Issued US Patent 5,493,109, 2/20/96. Filed 8/18/94.

“Method and Apparatus for Optical Coherence Tomographic Fundus Imaging without Vignetting” Issued US Patent 5,537,162, 6/16/96. Filed 12/17/93.

“Method and Apparatus for High Speed Longitudinal Scanning in Imaging Systems” Issued US Patent 6,191,862 2/20/01.

“Fiber Optic Needle Probes for Optical Coherence Tomography Imaging” Patent Pending.

“Micro-Lens for Miniature Optical Probes” Patent Pending.

“Method and Apparatus for Performing Optical Frequency Domain Reflectometry” Issued US Patent 6,160,826. 12/12/00. Filed 1999.

“Broadband Light Source System and Method Thereof” Patent Pending.

“Apparatus and Method for Selective Data Collection and Signal to Noise Ratio Enhancement Using Optical Coherence Tomography” Patent Pending Filed 4/6/01.

“Fiber Optic Endoscopic Gastrointestinal Probe” Patent Pending.

IPSCIO Record ID: 6021

License Grant
The University has granted the Licensee an exclusive license for patents and patent applications in the field of Optical Coherence Imaging technology for dental applications in humans and animals, in the United States. The Licensor also grants to Licensee the right to issue royalty-bearing subLicenses to third parties in the Field of Use.
License Property
United States Patents Granted

5,570,182 Method for Detection of Dental Caries and Periodontal Disease Usin Optical
6,179,611 Dental Optical Coherence Domain Reflectometry Explorer

Optical Coherence Tomography, or ‘OCT’, is a technique for obtaining sub-surface images of translucent or opaque materials at a resolution equivalent to a low-power microscope. It is effectively ‘optical ultrasound’, imaging reflections from within tissue to provide cross-sectional images.

Field of Use
The field of Optical Coherence Imaging technology for dental applications in humans and animals.

IPSCIO Record ID: 6066

License Grant
The Licensee exclusively licensed a portfolio of seven patents from the University for diagnostic products used in the dental field.
License Property
Optical Coherence Tomography (OCT) is generally regarded as the 6th Imaging Modality and is a new, light-based system with characteristics that make it ideally suited to bio-medical diagnostic imaging applications.  OCT represents a major advancement in imaging in dentistry due its ability to provide detailed characterization of the dental microstructures, enabling the dentist to make earlier and more accurate diagnosis of oral disease including decay and periodontal disease.  The early detection of tooth decay facilitates the dentist to employ non- or minimally invasive techniques to treat or even reverse decay and periodontal disease.  Less invasive treatment enhances the patient experience and results in a higher level of professional service and patient care. The proprietary OCT Dental Imaging System(TM) will be used by dentists to obtain a real-time chairside evaluation of the oral tissues to aid in the early detction of decay, periodontal disease and microstructural deficiencies.

In general, Optical Coherence Tomography, or ‘OCT’, is a technique for obtaining sub-surface images of translucent or opaque materials at a resolution equivalent to a low-power microscope. It is effectively ‘optical ultrasound’, imaging reflections from within tissue to provide cross-sectional images.

Patent No.
5,570,182; 6,179,611; 6,385,358; 6,419,484; 6,451,009; 6,466,713, 6,522,407

Field of Use
The rights granted apply to the dental field.

IPSCIO Record ID: 4853

License Grant
Licensor, an individual, hereby grants and Licensee hereby accepts an exclusive irrevocable license for use of the Technology in the human and veterinary medical fields, to produce, have produced, manufacture, have manufactured for it, to use and/or sell Patented Products to any distributor, reseller or end user (i.e., physicians, veterinarians, hospitals, clinics, universities or any other user), either separately or in combination with other products, and to use the Technology and Licensor Know-How in the specified fields, with the right to sublicense its Subsidiaries.
License Property
Licensor has invented, developed and filed patent applications relating to certain electronic endoscopes, flexible optical catheters, complementary viewing systems, and related disposable products for use in connection with detection, diagnosis and treatment of disease or injury in humans and animals.

1. OPTICAL CATHETER. All methods, apparatus, claims and products relating to certain products, processes and techniques described for use in and for a system consisting of a small diameter endoscope comprise of a sterilizable optical catheter which carries a coherent fiber-optic bundle capable of transmitting an image, and parallel fiber-optic bundles capable of transmitting light, which is coupled to an apparatus consisting of an eyepiece and/or console containing light source(s), camera(s) and viewing screen(s), as described in that certain patent application (No. 018,630) filed by Licensor with the U.S. Patent Office on February 25, 1987 (the 'Patent Application').

FLUORESCENCE DETECTION. A methodology of fluorescence detection allowing for the visualization of light emitting compounds from biological tissues and certain treatment applications thereon, using the Optical Catheter.
The optical catheter and fluorescence detection system includes, but is not limited to, the following
Endoscope with removable eyepiece, #018630
Optical catheter, ## 1,194,849 and 4,417,710
Laser endoscope, #4,589,404
Laser illuminator, #4,011,403
Steerable sheath for use with selected removable optical catheter, #5,325,845
Imaging tissue or stone removal basket, #5,311,858
Method and system for embollizing blood vessels, #4,869,246
Deflectable sheath for optical catheter, #07,581,592
Deformable and removable sheath for optical catheter, #07,581,591

2. THE ADAIR/VERESS NEEDLE. This device allows the introduction of gas, instruments, viewing devices and catheters into body cavities, particularly the abdominal cavity (peritoneum) including (but not limited to) the following
Gas insufflation needle with instrument port, #4,869,717

3. ELECTRONIC VIDEO LAPAROSCOPE. (a) All rigid video endoscopes with sterilizable sheath (all angles of view); (b) video endoscope with operative channels; thoracic endoscopes (rigid and deflectable); (c) 3-D technology on all endoscopes; sterile sheaths on all rigid endoscope products; and (d) all patents pending related to 'flipping of chip and bump bonding' for use in all endoscopic applications; all of which, (being described in clauses (a), (b), (c), and (d) above, including (but not limited to) the following
Rigid video endoscope with sterilizable sheath, #4,878,485, reissue #33,845
Heat sterilizable electronic video laparoscope, #5,188,094 Stereoscopic endoscope, #5,381,784
Operative electronic video laparoscope, subsequently abandoned
Miniaturized electronic imaging chip, #07,954,550, subsequently abandoned, continuation in part, #08,155,996

Field of Use
The term 'veterinary medical field' shall mean the field of veterinary applications and uses of the Technology to nonhuman animals including mammalian animals, and for the maintenance or improvement of health and/or growth or for the diagnosis, alleviation or cure of disease.

IPSCIO Record ID: 5266

License Grant
The Company agrees to sell, assign, transfer, set over and convey all rights, title and interest in and to said Original Agreement, including the exclusive licenses under U.S. Patent Nos. 4,284,895 and 4,437,006 in the Medical Field.  Patent Nos. 4,284,895 issued on August 18, 1981 relates to Method and apparatus for tomographic examination of an object by penetrating radiation and Patent Nos. 4,437,006 issued on March 13, 1984 relates to Method and apparatus for measuring radiation in computer-assisted tomography and radiographic applications.
License Property
Technology relates to the construction of an x-ray tomographic scanning prototype.

The Company has an exclusive license for the worldwide rights in the medical field to two patents for its proposed medical imaging camera. The two patents relate to high-speed single photon counting cameras and camera configurations which minimize the “noise” associated with the scattering of low energy photons.

IPSCIO Record ID: 299232

License Grant
Licensor grants a nontransferable, nonexclusive, worldwide license under Licensors Patent Rights and Technical Information to make, but not have made, use for internal array development programs and pharmaceutical or diagnostic research, such use rights not including the right to license or distribute expression databases, or perform therapeutic or pharmaceutical development on a service or similar basis, import, lease, distribute, offer for sale, and sell, in the case of products other than software;  Genetic Analysis Technology Consortium or GATC Compliant Nucleic Acid Arrays, and.  GATC Compliant Systems for use with and only for use with GATC Compliant Nucleic Acid Arrays licensed hereunder, all to the extent that such Nucleic Acid Arrays or Systems are covered by Licensor Patent Rights and/or Licensors Technical Information.

Licensor grants to Licensee a nontransferable, nonexclusive, worldwide, royalty-free license under Licensor -Patent Rights to make (but _not have made); ·and· use Array Makers for internal array.
development and manufacturing development programs.

License Property
Licensor has Technical Information which includes a software suite for data extraction and image processing.

The Licensed software packages are GeneChip® System Software and GeneChip Expression Analysis Software.

System shall mean one or more readers, hybridization devices, computer work stations, and/or single copies of software associated therewith specifically configured for use with Nucleic Acid Arrays and to be used for extraction and processing of data from such Nucleic Acid Arrays, and not including, for example, Array Makers.

Array Maker shall mean a device designed to fabricate Nucleic Acid Arrays by Mechanical Fabrication Methods and specifically configured to fabricate only Nucleic Acid Arrays only by Mechanical Fabrication Methods.

Gene shall refer to a nucleic acid sequence encoding a distinct messenger RNA and protein as well as polymorphic variants of such sequence.

Field of Use
The field of use is software useful in connection with Nucleic Acid Arrays, and to be used for extraction and processing of data from such Nucleic Acid Arrays.

IPSCIO Record ID: 2126

License Grant
The Company hereby grants to Licensee an exclusive, non-transferable, non-divisible license to make, have, made, use, offer to sell, and sell Licensed Products covered by the Claims of the Patents throughout the Territory on the terms and provisions hereof.
License Property
U.S. Patents means (i) the Application for Letters Patent identified as Case No. 96,242 titled A Method and Apparatus for Imaging and Sampling Diseased Tissue Using Autofluorescence as filed under United States Patent Application Serial No. 08/845,261 on April 23, 1997, (ii) Case No. 96,242-A, which is a continuation in part thereof, as filed under United States Patent Application Serial No. 08/951,018 on October 15, 1997.
Field of Use
The rights granted apply to diseased tissues.

IPSCIO Record ID: 27222

License Grant
The Licensor granted the Licensee a non-exclusive sublicense in the field of hair removal under the MGH patents.  Patented invention pertaining to the use of lasers for hair removal; LightSheer diode laser system (Patent No.  5,595,568).
License Property
United States Patent No. 5,595,568  (Permanent Hair Removal Using Optical Pulses).
Field of Use
The rights granted apply to hair removal.

IPSCIO Record ID: 233446

License Grant
Licensor grants the exclusive, world-wide license under Licensor’s rights in the Licensed Patents to make, have made, use, market and/or sell Products designed and marketed solely for use in the Field of Use; with the right to grant sublicenses to Sublicensees.

Licensor grants the world-wide right to practice the Technology to make, have made, use, market and/or sell Products designed and marketed solely for use in the Field of Use.

License Property
The patents include Multiwavelength Laser Source, Method for Reshaping the Eye, and,  Method for Removing Cataractous Material.

The Product(s) shall mean any goods or services whose manufacture, use or sale in any country would, but for this Agreement, comprise an infringement, including contributory infringement, of one or more Valid Claims; and any goods or services incorporating, or the manufacture, use or sale of which utilizes the Technology.

The technology shall mean all information, manufacturing techniques, data, designs or concepts, whether or not such specific information, manufacturing techniques, data, designs or concepts are or become publicly known or available, developed by Licensor which relate to methods and apparatus for laser-assisted opthalmic surgical procedures.

Field of Use
Field of Use shall refer to use of ultrafast laser medical instruments for human health and human cosmetic applications.

IPSCIO Record ID: 286021

License Grant
University hereby grants to Licensee, subject to the terms herein recited, the exclusive, nontransferable (except as provided in Agreement herein) perpetual, royalty bearing, worldwide right and license under the Patent Rights with the right to grant sublicenses, to make, have made, use, sell and distribute (directly or indirectly through third parties) Licensed Products.
License Property
Patent Rights shall mean
(a)  U.S. Patent 4,710,030, Optical generator and detector of stress pulses.
(b)  U.S. Patent 5,706,094, Ultrafast optical technique for the characterization of altered materials
(c)  U.S. Patent 5,864,393, Optical method for the determination of stress in thin films.
(d)  U.S. Patent 5,748,317, Apparatus and method for characterizing thin film and interfaces using an optical heat generator and detector.
(e)  U.S. Patent 5,748,318, Optical stress generator and detector.
(f)  U. S. Patent 5,844,684, Optical method for determining the mechanical properties of a material.

Licensed Product shall not, however, include (i) replacement parts provided or sold to end-users after the initial system is delivered; (ii) all software provided after delivery which does not provide additional  functional capabilities which incorporates the claims of the Patent Rights; (iii) software upgrades or revisions which do not provide additional functional capabilities which incorporates the claims of the Patent Rights; (iv) service and maintenance of hardware and/or software and peripherals to the system.  For purposes of this Agreement, a product shall be deemed a Licensed Product if such product is covered, in whole or in part, by at least one Patent Right in one country, whether or not that product is made, used or sold within that country.  For example, an instrument system that incorporates one of the claims of U.S. Patent 4,710,030 would be a Licensed Product and would be subject to a royalty payment if sold in Japan, even though there is no issued patent in Japan.

Field of Use
This agreement pertains to the semiconductor industry relating to the measurement of the properties of thin films and surface characteristics; and semiconductor metrology automation platforms (FE-III, FE-IV) including, an automatic microscope, auto height, tilt optics platform, automated wafer handling robotics and control system with proprietary software, operation interface, pattern recognition system SECS-II/GEM system, data mapping system, data review system and recipe system, with attendant know-how, process technology and related software; and technology to industry of instruments for the measurement of surface characteristics.

Metal and Opaque Thin Film Measurement Solutions. Licensee's MetaPULSE family of metrology systems incorporates our proprietary technology for optical acoustic metrology, which allows customers to simultaneously measure the thickness and other properties of up to six metal or other opaque film layers in a non- contact manner on product wafers. By minimizing the need for test wafers, MetaPULSE enables Licensee's customers to achieve significant cost savings. Licensee believe that Licensee currently offer the only systems that can non-destructively measure up to six metal film layers with the degree of accuracy semiconductor device manufacturers demand. Licensee's MetaPULSE systems use ultra-fast lasers to generate sound waves that pass down through a stack of metal or opaque films such as copper and aluminum, sending back to the surface an echo which is detected and analyzed. These systems precisely measure the films with Angstrom accuracy and sub-Angstrom repeatability at high throughputs. This accuracy and repeatability is critical to semiconductor device manufacturers' ability to achieve higher manufacturing yields with the latest fabrication processes.

IPSCIO Record ID: 28487

License Grant
The Licensor granted the Licensee a non-exclusive license agreement for the use of the patent rights and technology as they relate to cervical and ovarian cancer.
License Property
The Company agreed to settle an arbitration proceeding instituted by anther party against the Company through the transfer to the other party of certain patents, patent applications and other intellectual property rights relating to the AcCell technology.

The AcCell product is a computer-aided automated microscopy instrument designed to help medical specialists examine and diagnose specimens of human cells.

U.S. Patent 6,535,626; 6,430,309; 6,285,498; 6,148,096; 6,151,161; 6,118,581; 6,091,842; 6,081,740; 5,999,844; 5,963,368; 5,930,732; 5,833,794; 5,690,892; 5,077,806; 5,073,857

Field of Use
Licensed Field shall mean the field of products designed, developed, tested, manufactured, distributed, marketed, approved, sold, provided, and/or used exclusively for the screening of cervical or ovarian cancer which require the incorporation of  a fluorescent probe as its primary probe,  or which may incorporate other fluorescent or non-fluorescent probes, and in which the assay itself (a procedure employing one or more reagents which determines the biological state of a clinical specimen comprised of cells or tissues) is primarily fluorescent.

Licensee have designed and manufactured the AcCell(TM) computer-aided automated microscopy instrument and the AcCell Savant(TM), an instrument that includes an AcCell instrument and software and which collects quantitative cellular information used in support of a diagnostic process.

Licensee is a life sciences company engaged in the design, development and commercialization of cost-effective screening systems to assist in the early detection of cancer.

IPSCIO Record ID: 401

License Grant
The Company hereby grants to Licensee an exclusive, non-transferable non-divisible license to make, have made, use, offer to sell and sell Licensed Products covered by the U.S. Patents and Foreign Patents for use in cervical and ovarian gynecological applications for Point of Care and concurrent with a patient’s medical office visit in a physician’s office and the non-exclusive license to make, have made, use, offer to sell and sell Licensed Products covered by the U.S. Patents and Foreign Patents for use in cervical and ovarian gynecological applications for Point of Care in labs outside of the physician's office.
License Property
U.S. Patents means (i) AccuMed’s Patent entitled A Method and Apparatus For Imaging and Sampling Diseased Tissue Using Autofluorescence U.S. patent number 5,999,844 dated 12/07/99; (ii) the continuations, continuations-in-part or divisions thereof, if any; and (iii) any and all improvements, modifications, extensions, renewals or reissues of such Patent, if any.
Field of Use
This License Agreement is with respect to U.S. Patents and Foreign Patents rights for use in cervical and ovarian gynecological applications.

IPSCIO Record ID: 27303

License Grant
TWI hereby grants to Japanese company the exclusive right and license, without right of sublicense, to use the TWI Intellectual Property Rights to manufacture, use and sell Products (including those incorporating Improvements) to customers for use in non-semiconductor applications, such as flat panel display.
License Property
OP-LCD System is film measurement system for customers for use in non-semiconductor applications using Beam Profile Reflectometry technology and consisting of (1) Measurement Optics, (2) Sample Stage, (3) Control System and (4) Software, details of which are as follows Patent No. 4,999,014  Method and apparatus for measuring thickness of thin films; 5,042,951  High-resolution ellipsometric apparatus; 5,159,412  Optical Measurement Device with enhanced sensitivity; 5,181,080  Method and apparatus for evaluating the thickness of thin films.

(1)  Measurement Optics

     a. Optics for Beam Profile Reflectometry

     b. Optics for Spectrometry (optional)

     c. Optics for Ellipsometry (optional)

(2)  Sample Stage

     a. XY-0 Stage System

     b. Isolation Unit

(3)  Control System

     a. Main Control System

     b. Auto-focus System

     c. Video Monitoring System

     d. Pattern Recognition System

(4)  Software

     a.   TFMS

     b.   IOPT

Licensed Trademarks
1. Therma-Wave
2. Opti-Probe

IPSCIO Record ID: 25927

License Grant
The University Foundation agrees to extend Licensee's right to exclusive, transferable worldwide, irrevocable licenses in foundation technology.  Terms and conditions of said licenses are set forth in the agreement entered into in 1992.
License Property
Foundation and Licensee previously entered into a Research Agreement for the development and commercialization of said technology dated June 1, 1992 and amended said agreement from time to time, the last amendment being August of 2001.

Medical Diagnostic Optical technology
1. #5,042,494, August 27, 1991, Method and Apparatus for Detecting Cancerous Tissue using Luminescence Excitation Spectra, R. R. Alfano.
2. #5,131,398, July 21, 1992, Method and Apparatus for Distinguishing Cancerous Tissue from Benign Tumor Tissue, Benign Tissue or Normal Tissue using Native Fluorescence, R. R. Alfano, B. Das, G. Tang.
3. #5,261,410, November 16, 1993, Method for determining if a Tissue is a Malignant Tumor Tissue, a Benign Tumor Tissue, or a Normal Benign Tissue using Raman Spectroscopy, R. R. Alfano, C.-H. Liu, W. S. Glassman.
4. #5,293,872, March 15, 1994, Method for Distinguishing between Calcified Atherosclerotic Tissue and Fibrous Atherosclerotic Tissue or Normal Cardiovascular Tissue Using Raman Spectroscopy, R. R. Alfano, C. H. Liu
5. #5,348,018, September 20, 1994, Method for determining if Tissue is Malignant as opposed to Non-Malignant using Time-Resolved Fluorescence Spectroscopy, R. R. Alfano, A. Pradhan, G. C. Tang, L. Wang, Y. Budansky, B. B. Das.
6. #5,413,108, May 9, 1995, Method and Apparatus for Mapping a Tissue Sample for and Distinguishing Different Regions thereof based on Luminescence Measurements of Cancer-indicative Native Fluorophor, R. R. Alfano.
7. #5,467,767, November 21, 1995, Method for Determining if Tissue is Malignant as opposed to Non-Malignant using Time-resolved Fluorescence Spectroscopy, R. R. Alfano, Asima Pradhan, G. C. Tang, L. Wang, Y. Budansky, B. B. Das.
8. #5,635,402, June 3, 1997. Technique for Determining whether a Cell is Malignant as opposed to Non-malignant using Extrinsic Fluorescence Spectroscopy, R. R. Alfano, Cheng H. Liu, Wei L. Sha, Yury Budansky.
9. #5,769,081, June 23, 1998, Method for Detecting Cancerous Tissue using Optical Spectroscopy and Fourier Analysis, R. R. Alfano, A. Katz, Y. Yang.
10. #5,849,595, December 15, 1998, Method for Monitoring the Effects of Chemotherapeutic Agents on Neoplasmic Media, R. R. Alfano, G. C. Tang, S. P. Schantz.
11. #5,983,125, November 9, 1999, Method and apparatus for in vivo examination of subcutaneous tissues inside an organ of a body using optical spectroscopy, R. R. Alfano, Y. Budansky.
12. #6,006,001, December 21, 1999, Fiber optic assembly useful in optical spectroscopy, R. R. Alfano, S. Demos, G. Zhang.
13. #6,080,584, June 27, 2000, Method and apparatus for detecting the presence of cancerous and precancerous cells in a smear using native fluorescence spectroscopy, Robert R. Alfano, Singaravelu Ganesan, and Yury Budansky.
14. #6,091,985, July 18, 2000, Detection of cancer and precancerous conditions in tissues and/or cells using native fluorescence excitation spectroscopy, Robert R. Alfano, Singaravelu Ganesan, Alvin Katz, Yang Yuanlong.

Optical Imaging for Medical Purposes
1. #5,371,368, December 6, 1994, Ultrafast Optical Imaging of Objects in a Scattering Medium, R. R. Alfano, P. P. Ho, L. Wang.
2. #5,625,458, April 29, 1997, Method and System for Imaging Objects in Turbid Media using Diffusive Fermat Photons, R. R. Alfano, A. Y. Polishchuk.
3. #5,644,429, July 1, 1997 (see #5,371,368), 2-Dimensional Imaging of Translucent Objects in Turbid Media, R. R. Alfano, P. P. Ho, X. Liang.
4. #5,710,429, January 20, 1998, Ultrafast Optical Imaging of objects in or Behind Scattering Media, R. R. Alfano, Feng Liu, Q. Z. Wang P. Ho, L. M. Wang, X. Liang.
5. #5,719,399, February 17, 1998, Imaging and Characterization of Tissue based upon the Preservation of Polarized Light transmitted therethrough, R. R. Alfano, S. G. Demos.
6. #5,799,656, September 1, 1998, Optical Imaging of Breast Tissues to enable the Detection therein of Calcification Regions Suggestive of Cancer, R. R. Alfano, P. P. Ho, L. Wang, X. Liang, P. Galland.
7. #5,813,988, September 29, 1998, Time Resolved Diffusion Tomographic Imaging in Highly Scattering Turbid Media, R. R. Alfano, W. Cai, F. Liu, M. Lax, Bidyut B. Das.
8. #5,847,394, December 8, 1998, Imaging of Objects Based upon the Polarization or Depolarization of Light, R. R. Alfano, S. G. Demos.
9. #5,931,789, August 3, 1999, Time-resolved diffusion tomographic 2D and 3D imaging in highly scattering turbid media, Robert R. Alfano, Wei Cai, Feng Liu, Melvin Lax.
10. # 6,208,886 B1, March 27, 2001, Non-linear optical tomography of turbid media, Robert R. Alfano, Yici Guo, Feng Liu, Ping Pei Ho.
11. # 6,215,587, April 10, 2001, Microscope imaging inside highly scattering media, Robert R. Alfano, Gordon Anderson, Feng Liu.

Field of Use
Patent relates to cancer detection apparatus using visible luminescence.

IPSCIO Record ID: 27509

License Grant
The Company’s Chief Executive Officer grants to Licensee  the exclusive right to modify, customize, maintain, incorporate, manufacture, sell, and otherwise utilize and practice the above stated Patent, all improvements thereto and all technology related to the process, throughout the world. This license shall apply to any extension or re-issue of the Patent.
License Property
The CTLM employs a high-speed pico-second pulsed titanium sapphire laser and proprietary scanning geometry and reconstruction algorithms to detect and analyze masses in the breast indicia of malignancy or benignancy.  A device for detecting breast cancer through the skin in a non-invasive and objective procedure.

Patent number 5,692,511, issued on December 2, 1987

Field of Use
Licensee is a medical technology company that has developed a Computed Tomography Laser Mammography (system for detecting breast cancer through the skin in a non-invasive and objective procedure, which incorporates the use of the Patent (the CTLM).

IPSCIO Record ID: 26489

License Grant
The Company hereby grants to Licensee an exclusive, worldwide, royalty-bearing, limited license under the Licensed Technology to make, have made, import, use, sell and have sold the Devices solely within the Field of Use.
License Property
U.S. 5,860,934                    Method and Device for Mechanical Imaging of Breast         Issued 01/19/99

(CIP of App. 07/994,109)

U.S. 5,833,633                    Device for Breast Haptic Examination                       Filed 11/03/97

(CIP of 5,524,636)                                                                           Issued 11/10/98

U.S. 5,785,633                    Method and Device for Mechanical Imaging of Prostate       Filed 02/27/96

(CIP of 5,524,636)                                                                           Issued 07/28/98

U.S. 5,836,894                    Apparatus for Measuring Mechanical Parameters of the       Filed 06/10/97

(CIP of 5,524,636)                Prostate and for Imaging the Prostate Using such           Issued 11/17/98

U.S. 5,922,018                    Method for Using a Transrectal Probe to Mechanically        Filed 06/10/97

(CIP of 5,524,636)                Image the Prostate Gland                                    Issued 07/13/99

U.S. 5,524,636                    Method and Apparatus for Elasticity Imaging                Filed 12/21/92

U.S. 5,265,612                    Intracavity Ultrasonic Device for Elasticity Imaging       Filed 12/21/92

U.S. 6,142,959                    Device for Palpation and Mechanical Imaging of the         Filed 07/22/99

                                  Prostate                                                   Issued 11/07/00

PCT/US00/19756                    Device for Palpation and Mechanical Imaging of the         Filed 07/21/00

                                  Prostate

U.S. 09/843,056                   Apparatus and Method for Mechanical Imaging of Breast      Filed 04/26/01

PCT/US01/13551                    Apparatus and Method for Mechanical Imaging of Breast      Filed 4/26/01

U.S. 60/200,433                   Apparatus and Method for Mechanical Imaging of Breast      Filed 4/28/00

U.S. 09/819,419                   Real Time Mechanical Imaging of the Prostate               Filed 03/28/01

Field of Use
Field of Use shall mean the diagnosis of and the treatment of (a) benign prostatic hyperplasia; (b) prostatitis; © prostate cancer; or (d) any other conditions of or disorders of the prostate, whether healthy or diseased, and any other condition of urologic disorder which may be diagnosed, imaged or treated using any diagnostic or imaging process.  Prostate imaging system and related patented technology.

IPSCIO Record ID: 2111

License Grant
The Company grants a nonexclusive and nontransferable licenses to make, have made, use, lease, sell offer for sale and import Optical Fiber Sensing Systems.
License Property
Optical Fiber Sensing System means any instrumentality or aggregate of instrumentalities of a type for sensing any intrusion into an Optical Fiber or a network of Optical Fiber and includes all auxiliary apparatus associated therewith and involved in performing the function thereof.  Fiber Optic Intelligent Detection System (FOIDS(R)). Fiber optic based security system and components are used in the system that are immune to most external electronic impulses such as radio frequency emissions, static electricity (including lightning), and moisture and ambient temperature variations. Digital processing minimizes nuisance alarms and permits the operator to set the desired probability of detection (i.e., sensitivity to certain conditions or intrusions). The FOIDS(R) system can be fully integrated with a variety of digital security. The FOIDS(R) and RDIDS systems can be combined to create an easily deployable single-mode optical fiber sensor incorporating the most recent developments in optical and electronic technologies to provide state-of-the-art security in tactical situations where temporary barrier security is required.

PATENT means U.S. Patent 4,904,050 and any reissue thereof. Optical Fiber means a filamentary body of optical transmission material of a design primarily adapted for transmitting electromagnetic Waves having a frequency in excess of three hundred (300) GHz, along a desired path extending longitudinally there through and to which such Waves are substantially confined by the refraction of reflection (or both) of such Waves.

OPTICAL FIBER SENSING SYSTEM means any instrumentality or aggregate of instrumentalities of a type for sensing any intrusion into an OPTICAL FIBER or a network of OPTICAL FIBER and includes all auxiliary apparatus associated therewith and involved in performing the function thereof.

Field of Use
The rights granted apply solely for the manufacture in Licensee's factories of Optical Fiber Sensing Systems and of maintenance parts therefor.

IPSCIO Record ID: 294261

License Grant
Licensor hereby grants to Licensee and its Affiliates under all of Licensor’s rights in the Licensed IPR, a perpetual, world-wide, non-exclusive, right and license to fully use the Transferred Assets delivered hereunder in connection with the design, making, using, selling and maintenance of Licensed Products in the Field of Use.

Licensor hereby grants to Licensee and its Affiliates, under all of Licensor’s rights in the Licensed Patents, a limited, world-wide, non-exclusive, license to make and have made Licensed Products and to sell, offer for sale, import and use any such Licensed Products in the Field of Use; provided, however, that upon the fulfillment of Licensee’s Royalty obligations hereof, all Licenses granted by Licensor under this Agreement will become fully paid up.

All Licenses granted by Licensor to Licensee and its Affiliates hereunder shall be subject to any and all licenses and other agreements between Licensor and any third party or parties entered into prior to the Effective Date.

Licensor hereby sells, transfers, and assigns to Licensee, and Licensee purchases, assumes, and acquires from Licensor, all rights of Licensor (other than Intellectual Property Rights) in the following (collectively, the Transferred Assets). Licensor is willing to grant to Licensee, and Licensee is willing to accept, a royalty bearing license to manufacture and sell Lasers based upon the Licensor technology.

License Property
Business is a Clean Room operation where it manufactures certain swept-tunable Lasers.

Licensed IPR means any Intellectual Property Rights (other than Patents and Marks) owned or licensed by Licensor as of the Effective Date that are embodied by the Transferred Technology delivered under this Agreement and necessary to the manufacture, use and testing of the Transferred Lasers.

Licensed Patents means those Patents listed, which represent the Patents owned, licensed or controlled by Licensor and necessary to make and have made Licensed Products and to sell, offer for sale, import and use any such Licensed Products in the Field of Use.
U.S. Patent #6,912,235 – Apparatus and method for phase control of tunable external cavity lasers
U.S. Patent #6,903,486 – Balanced microdevice
U.S. Patent #6,882,083 – Miniature device with bossed suspension member

Licensed Product means any device or product that (i) embodies, comprises or incorporates Lasers; (ii) is made or developed using any Licensed IPR; (iii) is made, had made, used, offered for sale, sold or imported, by Licensee pursuant to the licenses granted under this Agreement; or (iv) is covered by a Valid Claim of the Licensed Patents.

Transferred Assets include but not limited to Equipment, Inventory, Software, Documentation and Intellectual Property Rights.

Licensor Lasers means the swept-tunable lasers, including the Transferred Lasers, manufactured by Licensor prior to the Effective Date using the Transferred Assets in the Clean Room.

Technology means all tangible embodiments, whether in electronic, written or other media, of all technology, including all techniques, design rules, inventions (whether or not patented or patentable), algorithms, routines, software, databases, processes, prototypes, and devices.

Intellectual Property Rights means the rights associated with the following (i) all United States and foreign patents and applications, including continuation, divisional and continuation-in-part applications thereof as well as any reissues and reexaminations thereof (Patents); (ii) all trade-secret rights and all other rights in or to confidential business or technical information (Trade Secrets); (iii) all copyrights, copyright registrations and applications therefor and all other rights corresponding thereto throughout the world (Copyrights); (iv) trademarks, service marks, trade dress rights and similar designation of origin and rights therein (Marks); and (v) any similar, corresponding or equivalent rights to any of the foregoing any where in the world. Intellectual Property Rights specifically excludes contractual rights, including license grants.

Transferred Lasers means the particular product form of swept-tunable Lasers that as of the date hereof are being manufactured by Licensor in the Clean Room and supplied to Licensee and the bill of materials for which product is listed in the Agreement.

Transferred Software means the software authored by, or on behalf of, or licensed by Licensor and used in the operation of the Clean Room and manufacture of the Transferred Lasers, including the control of the Transferred Equipment. The Transferred Software will include both source code and object code to the extent available.

Transferred Technology means all the Transferred Equipment, the Documentation and other Technology owned and transferable by Licensor that is included within the Transferred Assets or disclosed by Licensor to Licensee hereunder.

The Iolon laser is a miniaturized, external-cavity laser offering high performance in a compact footprint. Such lasers were designed with systems integration in mind and are applicable to a range of fiber optic test and measurement, instrumentation, and sensing applications.

Field of Use
Fields of Use means (i) for Lasers that operate from 1250 nm to 1700 nm, use in any application, and (ii) for Lasers that operate over any wavelength range other than the wavelengths set forth in the foregoing clause (i), for use only in applications in the fields of telecommunications, telecommunications test and/or coherent optical frequency domain reflectometry.

Tunable laser technology products employ frequency-tuned lasers to measure various aspects of the transmission properties of telecommunications fiber-optic components and systems. Lasers are also used in fiber-optic sensing applications such as distributed strain and temperature mapping, and distributed measurement of shape.

IPSCIO Record ID: 27725

License Grant
The Japanese Licensor grants to Licensee the non-exclusive license to develop, manufacture, sell and have sold the Licensee Products incorporating Licensor's Technology in Non-Pacific Rim Territories for the Medical Diagnostics Field.
License Property
Chip means a substrate which contains a grating pursuant to the Grating SPR Technology and is coated with a conductive surface.

Flow Cell means a device which allows liquids to flow through it and consist of a Chip and has an optically clear cover slip which is attached to the Chip by a means that allows for fluid flow there through.

Grating SPR Technology means the use of thin conductive films on a surface or surfaces of a grating or other diffracting substrate to conduct chemical analysis.

PATENT NO.                          TITLE                        JAPANESE PATENT NO.
—————————————————————————————-
  US 4,931,384           Optical Assay Technique (Merlin I)             JP 1903195
  US 5,118,608           Optical Assay Technique (Merlin I)             JP 2502222
  US 4,882,288           Assay Technique and Equipment                  JP 1928364
                         (Merlin II)
  US 4,992,385           Polymer-Coated Optical Structures              JP 2528134
                         and Methods of Making and Using                JP 2592588
                         the Same (Cellulose Nitrate Films)

  US 4,828,387           Film Measuring Device and Method               JP 2511057
                         with Internal Calibration to
                         Minimize the Effect of Sample
                         Movement (Calibration Notches)
  US 5,310,686           Polymer-Coated Optical Structures              JP 2710243
                         (Sensor Using Photoresist)
  CA 1,302,875           (Waveguide Sensor)                             JP 2572829
  US 6,093,536           (Enhanced SPR Assay)                           JP 2073383

Field of Use
This agreement pertains to the medical diagnostics field.  Medical Diagnostics Field means those fields, the applications and products which under current laws and regulations of the United States would require approval of the United States Food and Drug Administration if the application or product incorporating the application were sold for clinical use in the United States.

IPSCIO Record ID: 476

License Grant
Licensor hereby grants an exclusive a royalty-bearing license, with the right to grant sublicenses under the Reliant Intellectual Property solely to make, have made, use, import, offer for sale and sell Products in the Field on a worldwide basis.
License Property
The technology involved includes CO2 laser accessories and scanners primarily for use in cosmetic and surgical applications.  U.S. Patent No. 5995265, 5786924, 5546214, 5420882, 5128509 and 5163936.
Field of Use
Field means use in surgical (including cosmetic and/or aesthetic) applications or veterinary applications.
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