Category: Technology Licenses
Created On: 2022-04-28
Record Count: 8
- Regenerative medicine
IPSCIO Report Record List
Below you will find the records curated into this collection. This summary includes the complete licensed property description so that you can review and determine if this collection covers the topics, technology or transaction type that is relevant for your needs. The full report will include all relevant deal data such as the royalty base, agreement date, term description, royalty rates and other deal terms. For reference, here is a sample of a full IPSCIO curated royalty rate report: Sample Report
IPSCIO Record ID: 369277
Licensor hereby grants to Licensee and Licensee accepts from Licensor, a non-exclusive, worldwide, right and license, including the right to sublicense, to the Know-How.
Licensor hereby grants to Licensee and Licensee accepts from Licensor for the Option Period (in each case) a non-transferable (except as specifically stated in Agreement), exclusive option to negotiate in good faith for a royalty-bearing, worldwide, exclusive license, including the right to sublicense, to practice all the rights under the New Development Patents in the Licensed Field only (the Option).
6,673,339 – Prosthetic kidney and its use for treating kidney disease
6,576,019 – Bladder reconstruction
6,514,292 – Corporal tissue penile reconstruction
The primary focus of the research will be on creating â€œneo-organsâ€ and tissues. Neo-organs and tissues are derived from a patientâ€™s own cells that are grown on a scaffold or model that is bioresorbable, or can be absorbed by the body. These neo-organs become functional replacements after being implanted in the patientâ€™s body. Since they come from a patientâ€™s own cells (autologous cells) there is virtually no risk of rejection from the bodyâ€™s immune system.
In tissue engineering, neo-organ is a final structure of procedure based on transplantation of constructs consisting of endogenous stem/progenitor cells grown ex vivo within predesigned matrix scaffolds. The scaffold eventually is resorbed, leaving transplanted cells and the stroma that they produce in the body.
Licensed Field means human and animal organs, tissues and tissue-engineered and regenerative medicine products directed to their functions in the following areas (i) Genitourinary Tissue, (ii) Kidney Tissue, (iii) Cardiovascular Tissue, (iv) Nervous Tissue, and (v) Trachea Tissue. Each of Genitourinary Tissue, Kidney Tissue, Cardiovascular Tissue and Nervous Tissue is a Subfield.
Genitourinary Tissue means the reproductive system and the urinary system, including the male and female internal and external genitalia as well as all organs concerned in the formation and voidance of urine, but excluding Kidney Tissue. For the removal of doubt, Genitourinary Tissue is not to be considered Cardiovascular Tissue merely because it contains components of Cardiovascular Tissue.
Kidney Tissue means the kidney.
Cardiovascular Tissue means arteries, arterial tissue, veins and venous tissue. Cardiovascular Tissue does not include cardiac muscle tissue or heart valves.
Nervous Tissue means the (i) central nervous system, (ii) peripheral nervous system, and (iii) functional subcomponents and subunits of (i) and (ii) above. For the removal of doubt, a tissue or organ is not considered Nervous Tissue merely because it contains components of Nervous Tissue.
Trachea Tissue means the trachea and functional subcomponents and subunits thereof. Trachea Tissue does not include the bronchus and larynx.
IPSCIO Record ID: 266751
Licensor also grants a non-exclusive license to Know-how, and a non-exclusive license to use Biological Materials in connection with licensees research and development of Licensed Products.
Biological Materials shall mean the specific proprietary biological materials, including Progeny and Unmodified Derivatives of those materials. Progeny shall mean an unmodified descendant from the material, such as a virus from virus, cell from a cell, or organism from an organism; Unmodified Derivatives shall mean substances created by the Licensee which constitute an unmodified functional subunit or product expressed by the original material, such as subclones of unmodified cell lines, purified or fractionated subsets of the original material, proteins expressed by DNA/RNA, or monoclonal antibodies secreted by a hybridoma cell line; and Modifications shall mean substances created by the Licensee which contain or incorporate the material.
IPSCIO Record ID: 2550
A. ISSUED U.S. PATENTS
4,721,096 Process for Replicating Bone Marrow In Vitro and Using the Same
4,960,489 Three-Dimensional Cell and Tissue Culture System
5,032,508 Three-Dimensional Cell and Tissue Culture System
5,160,490 Three-Dimensional Cell and Tissue Culture System Apparatus
5,266,480 Three-Dimensional Skin Culture System
5,443,950 Three-Dimensional Cell and Tissue Culture System
5,460,939 Temporary Living Skin Replacement
5,478,739 Three-Dimensional Stromal Cell and Tissue Culture System
5,510,254 Three-Dimensional Cell and Tissue Culture System
5,512,475 Three-Dimensional Skin Cell and Tissue Culture System
5,516,680 Three-Dimensional Kidney Cell and Tissue Culture System
5,516,681 Three-Dimensional Pancreatic Cell and Tissue Culture System
5,518,915 Three-Dimensional Mucosal Cell and Tissue Culture System
5,541,107 Three-Dimensional Bone Marrow Cell and Tissue Culture System
5,559,022 Liver Reserve Cells
5,578,485 Three-Dimensional Blood-Brain Cell and Tissue Culture System
5,580,781 Three-Dimensional Tumor Cell and Tissue Culture System
5,599,788 Method for Accelerating Skin Wound Healing with H3 Protein
5,624,840 Three-Dimensional Liver Cell and Tissue Culture System
5,714,588 Enhancement of Cellular Attachment Using H3 Protein
5,763,267 Apparatus for the Large Scale Growth and Packaging of Cell
Suspensions and Three-Dimensional Tissue Cultures
5,785,964 Three-Dimensional Genetically Engineered Cell and Tissue Culture
5,792,603 Apparatus and Method for Sterilizing, Seeding, Culturing, Storing,
Shipping and Testing Tissue, Synthetic or Native, Vascular Grafts
5,827,729 Diffusion Gradient Bioreactor and Extracorporeal Liver Device
Using a Three-Dimensional Liver Tissue
5,830,708 Methods for Production of a Naturally Secreted Extracellular Matrix
5,842,477 Method for Preparing Cartilage
5,843,766 Apparatus for the Growth and Packaging of Three Dimensional
5,846,828 Apparatus and Method for Sterilizing, Seeding, Culturing,
Storing, Shipping and Testing Tissue, Synthetic, or Mechanical
Heart Valves or Valve Segments
5,849,588 Methods of Use of a Three-Dimensional Liver Cell and Tissue
5,858,721 Three-Dimensional Cell and Tissue Culture System
5,863,531 In Vitro Preparation of Tubular Tissue Structures by Stromal Cell
Culture on a Three-Dimensional Framework
5,902,741 Three Dimensional Cartilage Cultures
5,919,702 Production of Cartilage Tissue Using Cells Isolated From
5,928,945 Application of Shear Flow Stress to Chondrocytes or Chondrocytre
Stem Cells to Produce Cartilage
5,962,325 Three-Dimensional Stromal Tissue Cultures
6,008,049 Diffusion Gradient Bioreactor and Extra-Corporeal Liver Device
6,022,743 Three-Dimensional Culture of Pancreatic Parenchymal Cells
Cultured Living Stromal Tissue Prepared In Vitro
6,027,935 Gene Up-Regulated in Regenerating Liver
6,060,306 Apparatus and Method for Sterilizing, Seeding, Culturing, Storing,
Shipping and Testing Replacement Cartilage Tissue Constructs
6,121,042 Apparatus and Method for Simulating In Vivo Conditions While
Seeding And Culturing Three-Dimensional Tissue Constructs
6,140,039 Three-Dimensional Filamentous Tissue Having Tendon or Ligament
6,218,182 Method For Culturing Three-Dimensional Tissue in Diffusion
Gradient Bioreactor and Use Thereof
6,284,284 Compositions and Methods for Production and Use of an Injectable
Naturally Secreted Extracellular Matrix
6,291,240 Cells or Tissues With Increased Protein Factors and Method of
B. PENDING U.S. PATENT APPLICATIONS
08/488,165 Three-Dimensional Human Cell Cultures on Cardiac Valve Frameworks
and Their Uses – on appeal
08/660,787 Compositions and Methods for Production and Use of an Injectable,
Naturally Secreted Extracellular Matrix
09/256,649 Living Chimeric Skin Replacement
09/313,538 Conditioned Cell Culture Medium Compostions and Methods of Use
09/362,948 Genetically Engineered Cells Responsive to Environmental Cues
09/350,386 Human Naturally Secreted Extracellular Matrix-Coated Device and
Methods for the Production and Uses Thereof
09/401,445 Three Dimensional Human Cell Cultures on Cardiac Valve Frameworks
and Their Uses
09/411,585 Methods of Using a Three-Dimensional Stromal Tissue to Promote
09/457,519 Application of Shear Flow Stress to Smooth Muscle Cells for the
Production of Implantable Structures
09/482,203 Apparatus and Method for Sterilizing, Seeding, Cultiring, Storing,
Shipping and Testing Tissue Synthetic or Native Vascular Grafts
09/603,642 Monitorable Three Dimensional Scaffolds and Tissue Culture
09/724,410 Cells or Tissues with Increased Protein Factors and Methods for
09/847,902 Container for Shipping Tissue
60/297,177 Compositions Comprising Conditioned Cell Culture Media and Uses
II. UNITED STATES PATENTS LICENSED TO ADVANCED TISSUE SCIENCES, INC.
A. LICENSED FROM THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY
4,418,691 Method of Promoting the Regeneration of Tissue at a Wound
4,458,678 Cell-Seeding Procedures Involving Fibrous Lattices
4,505,266 Method of Using a Fibrous Lattice
4,638,045 Non-Peptide Polyamino Acid Bioerodible Polymers
4,806,621 Biocompatible, Bioerodible, Hydrophobic, Implantable Polyamino
4,947,840 Biodegradable Templates for the Regeneration of Tissues
5,041,138 Neomorphogenesis of Cartilage In Vivo From Cell Culture
5,128,420 Method of Making Hydroxamic Acid Polymers From Primary Amide
5,399,665 Biodegradable Polymers For Cell Transplantation
5,514,378 Biocompatible Polymer Membranes and Methods of Preparation of Three
Dimensional Membrane Structures
5,516,532 Injectable Non-Immunogenic Cartilage and Bone Preparation
5,654,381 Functionalized Polyester Graft Copolymers
5,736,372 Biodegradable Synthetic Polymeric Fibrous Matrix Containing
Chondrocyte For In Vivo Production of a Cartilaginous Structure
5,759,830 Three-Dimensional Fibrous Scaffold Containing Attached Cells for
Producing Vascularized Tissue In Vivo
5,770,193 Preparation of Three-Dimensional Fibrous Scaffold For Attaching
Cells to Produce Vascularized Tissue In Vivo
5,770,417 Three-Dimensional Fibrous Scaffold Containing Attached Cells for
Producing vascularized Tissue In Vivo
5,804,178 Implantation of Cell-Matrix Structure Adjacent Mesentery, Omentum or
6,123,727 Tissue Engineered Tendons and Ligaments
6,095,148 Neuronal Stimulation Using Electrically Conducting Polymers
6,224,893 Semi-Interpenetrating or Interpenetrating Polymer Network for Drug
Delivery and Tissue Engineering
B. LICENSED FROM THE UNIVERSITY OF FLORIDA
5,650,299 Cells Producing Stem Cell Proliferation Factor
5,981,708 Stem Cell Proliferation Factor
IPSCIO Record ID: 283919
Through this License, Licensee intellectual property broadly covers the development of extracellular matrix scaffolds derived from ovine rumen and methods for isolating these scaffolds from ovine rumen.
OviTex Reinforced Tissue Matrix, or OviTex, addresses unmet needs in hernia repair and abdominal wall reconstruction by combining the benefits of biologic matrices and polymer materials. OviTex PRS, addresses unmet needs in plastic and reconstructive surgery.
OviTex PRS is indicated for use in implantation to reinforce soft tissue where weakness exists in patients requiring soft tissue repair or reinforcement in plastic and reconstructive surgery.
Licensee is a commercial stage medical technology company focused on designing, developing and marketing a new category of tissue reinforcement materials to address unmet needs in soft tissue reconstruction. Licensee offer a portfolio of advanced reinforced tissue matrices that improve clinical outcomes and reduce overall costs of care in hernia repair, abdominal wall reconstruction and plastic and reconstructive surgery. Licensee products are an innovative solution that integrate multiple layers of minimally-processed biologic material with interwoven polymers in a unique embroidered pattern, which we refer to as a reinforced tissue matrix.
IPSCIO Record ID: 29009
An implantable human heart valve treated with growth factor effective on fibroblast cells and populated with fibroblast cells in an amount and for a time period effective for rendering the heart valve substantially non-immunogenic upon implant into a mammal. An implantable non-human mammalian heart valve treated with growth factor effective on fibroblast cells and populated with fibroblast cells in an amount and for a time period effective for rendering the heart valve substantially non-immunogenic upon implant into a mammal.
IPSCIO Record ID: 230517
The IP includes products and technologies like MyoCell for the treatment of heart damage. These are autologous muscle-derived cellular therapies designed to populate regions of scar tissue within a patientâ€™s heart with new living cells for the purpose of improving cardiac function in chronic heart failure patients.
MyoCell is an innovative clinical therapy designed to populate regions of scar tissue within a patientâ€™s heart with autologous muscle cells, or cells from a patientâ€™s body, for the purpose of improving cardiac function in chronic heart failure patients.
IPSCIO Record ID: 5464
Orton Patents include, but are not limited to, U.S. Patent Nos. 5,192,312; 5,772,695; 5,863,296; 5,855,617, and U.S. Provisional Application Serial No. 60/219,548 as well as corresponding Non-Provisional Application Serial No. 09/909914 and PCT Application Serial No. PCT/US01/22018.
Goldstein Patents shall mean U.S. Patent Nos. 5,613,982; 5,632,778; 5,843,182; 5,899,936; and all pending and future applications and patents, both U.S. and foreign, arising from these patents, as well as any continuations, continued prosecution applications, continuations-in-part, divisions, or substitutions thereof.
Tissue Decellularization Patent Applications shall mean U.S. Application Serial Nos. 08/838,852 and 09/735,522 and all pending and future applications.
Tissue Graft Patent Applications shall mean U.S. Application Serial Nos. 60/178,632 and 09/769,769 and all pending and future applications and patents.
Unstented Heart Valve Patent Applications shall mean U.S. Application Serial No. 09/540,525 and all pending and future applications and patents, both U.S. and foreign, arising from these patents, as well as any continuations, continued prosecution applications, continuations-in-part, divisions, or substitutions thereof.
IPSCIO Record ID: 356974
lmprovements mean any Intellectual Property developed after the Effective Date by the Inventor/Licensor or any third party affiliated with Licensor that constitutes an improvement or enhancement of the functions of the Technology, that is associated to the Technology and that relates to a bioreactor device able to feed and repopulate a rotating tubular structure, with the exclusion of different or new functions relating to generation of electrical fields, pressure fields and fluid dynamic fields.
This bioreactor is the first in a series of products that Licensee is developing to address what we believe is a long-term growth opportunity in the emerging field of regenerative medicine. Regenerative medicine is a new field that uses stem cells to repair damaged organs (e.g., spinal cord and heart) and also to grow tissue (e.g., bladder and bronchus) and organs (e.g., heart and lung) outside the body for transplant.
InBreath hollow organ bioreactor is a device that can be used by a surgeon to seed cells onto a scaffold. The InBreath bioreactor enables the surgeon to
secure the scaffold to the bioreactor;
seed the patientâ€™s cells on the scaffold under sterile conditions;
automatically rotate the scaffold to allow good cell distribution into the pores of the scaffold; and
remotely monitor the scaffold during the course of the two to three days incubation period before the transplant.
The InBreath bioreactor has several novel features such as allowing for separate cell seeding conditions on the inside and outside of the scaffold and for pumping cell culture media through the inside of the scaffold without the need for an external pump and tubes. The Licensee believe the InBreath hollow organ bioreactor is the worldâ€™s first bioreactor that has been used to perform a human transplant of a regenerated organ.
The Technology has proven beneficial medical uses in organ transplant as well as the potential for use in other areas.