Category: Technology Licenses
Created On: 2022-04-28
Record Count: 3
- Drug Discovery
IPSCIO Report Record List
Below you will find the records curated into this collection. This summary includes the complete licensed property description so that you can review and determine if this collection covers the topics, technology or transaction type that is relevant for your needs. The full report will include all relevant deal data such as the royalty base, agreement date, term description, royalty rates and other deal terms. For reference, here is a sample of a full IPSCIO curated royalty rate report: Sample Report
IPSCIO Record ID: 362480
As of the Effective Date, a Third Party and Licensee intend to enter into an (APA) Asset Purchase Agreement under which the Third Party will purchase all of Licensees right, title and interest in and to the Purchased Assets
This Agreement will govern the exclusive license of the Licensed Technology and Licensed Patents from Licensor to Licensee and the related rights and obligations under such license.
For the Grant of License to Licensee under Licensed Patents, Licensor grants to Licensee, and Licensee accepts, under the Licensed Patents, an exclusive license in the Field, with a right to sublicense, to make, have made, use, offer to sell, sell and import Product in the Territory. Such license is exclusive even as to Licensor except that Licensor retains a right under the Licensed Patents to make and use compound or product solely for internal research purposes.
For the Grant of License to Licensee under Licensed Technology, Licensor grants to Licensee, and Licensee accepts, under the Licensed Technology, an exclusive license in the Field, with a right to sublicense, to make, have made, use, offer to sell, sell and import Product in the Territory.
Monthly doses for treatment of Streptococcus Pneumoniae Infections;
Derivatives of A82846 and PA-82467A Glycopeptides;
Glycopeptide antibiotic derivatives;
N1 Modified Glycopeptides;
Urea and Thorea Derivatives of Glycopeptides;
Glycosyl Transferase Gene GTFA from Amycolatopsis Orientalis;
Reductive Alkylation of Glycopeptide antibiotics;
Selective N-Acylation of A82846 Glycopeptide analogs;
Selective N-Acylation Glycopeptide analogs;
Reducing agent for Reductive Alkylation of Glycopeptides;
Purification of Carboxaldehyde;
Therapy for Staphylococcus Aureus;
Glycopeptide Recovery Process;
Novel Glycopeptide Process;
Novel Glycopeptide Derivatives; and,
In two Phase III clinical trials with oritavancin for the treatment of complicated skin and skin-structure infections (â€œCSSSIsâ€), oritavancin achieved the primary efficacy endpoint and demonstrated that oritavancin was as effective as the comparator regimen of vancomycin followed by cephalexin, which is a commonly used regimen. However, the FDA requested an additional clinical safety study be completed prior to the submission of a New Drug Application, or NDA, for oritavancin for the treatment of CSSSIs
IPSCIO Record ID: 3412
IPSCIO Record ID: 305615
Collaboration Compound shall mean any composition of matter in the field (or in the case of pro-drugs, an active metabolite of which), other than a natural product or synthetic or semi-synthetic derivative thereof, that (i) was discovered, identified, synthesized or acquired by or on behalf of Licensor as of the effective date, (ii) is discovered, identified, synthesized or acquired by or on behalf of Licensor during the research term and for six (6) months thereafter, or (iii) is contained within a chemical genus as defined in any issued claim of any unexpired patent in the patent rights, or in a claim of a pending application for such a patent which is being prosecuted in good faith, and as to which one member of such chemical genus is defined in (i) or (ii) above. For purposes of determining whether a given composition is a collaboration compound, it is understood that a composition which is discovered, identified, synthesized or acquired during the research term or within six (6) months thereafter (the Applicable Date) shall be included as a collaboration compound notwithstanding whether the composition was identified as being active in the field after the Applicable Date.
Development shall mean all work involved in Phases O, I, II, and III for a Licensed product in any country or territory.
U.S. Serial No. 08/377,583 – Screening Procedure for Penicillin-binding protein inhibitors.
Research Program shall mean all research and development performed, directed or acquired by Licensor in the course of performing the research plan during the research term.
Licensor is a biopharmaceutical company founded to discover, develop and commercialize novel antibiotics for the treatment of serious bacterial infections. The Companys discovery and development programs address the growing problem of bacterial drug resistance through two principal themes (i) Targeted Antibiotics, which focuses on developing novel antibiotics and antibiotic potentiators, and (ii) Targeted Genomics, which utilizes bacterial genetics to discover new classes of antibiotics and other novel treatments for bacterial disease.
The targeted Antibiotics programs seek to rapidly develop clinically useful antibiotics tailored to treat specific bacterial infections, as well as antibiotic potentiators, which will overcome resistance pathways and restore usefulness to existing antibiotics that have been rendered ineffective. The specific problematic bacteria being addressed (staphylococci, enterococci, Pseudomonas aeruginosa and Streptococcus pneumoniae) are responsible for 44% of the approximately two million hospital-acquired infections occurring annually in the United States.
Field shall mean the field of
(i) cephalosporin antibiotics active against Gram-positive bacteria with MICs (minimum inhibitory concentrations) of ~ 32,/g/ml against staphylococci, enterococci and pneumococci, as determined by NCCLS recommended methods;
(ii) novel compounds and compositions which react with penicillin binding protein, including but not limited to PBP2a, with an ICso ! 50,/g/ml in a standard penicillin binding protein assay, provided that research activities are initiated in this ponion of the field prior to start of the nineteenth (19th) month of the research term;
(iii) non-antibacterial beta-lactam or glycopeptide antibiotic potentiators, including specifically, but not limited to, compounds that exen their e~ect primarily by inhibition of methicillin and vancomycin resistance mechanisms, and potentiators that exen their effect primarily by inhibition of histidyl-aspartyl two component switch regulatory system in bacteria, which non-antibacterial beta-lactam or glycopeptide antibiotic potentialOr exhibits MICs (minimum inhibitory concentrations) alone, against staphylococci, enterococci and pneumococci of ~32ys/ml. as determined by NCCLS recommended methods, but not including (a) quinolone potentiators or (b) potentiators or antibacterials which work primarily by inhibition of bacterial efflux pumps, or (c) beta-lactamase inhibitors ;
(iv) compounds or compositions discovered through the use of genes, gene products and Licensor screens in the Agr (accessory gene regulator) pathway of Staphylococcus aureus, or functionally homologous genes in other Gram-positive organisms, in either instance including histidyl-aspartyl two component switch regulatory systems in the Agr pathway;
(v) antibiotics which act through the histidyl-aspartyl two component switch regulatory system discovered using Licensor know-how developed in performance of the research program during the research term, or within six (6) months thereafter (i.e., new hits and leads and new discovery screens for histidine protein kinase inhibitors developed during the course of the research program), with MICs (minimum inhibitory concentrations) of~16/lg/ml against Gram-positive and/or Gram-negative organisms, as determined by NCCLS recommended methods, all for use in treating bacterial infections for all human and animal pharmaceutical applications.
Licensee has been engaged in research efforts focused on the development of new antibacterials and has certain research, development and commercialization capabilities in the field.