Category: Technology Licenses
Created On: 2022-04-28
Record Count: 8
IPSCIO Report Record List
Below you will find the records curated into this collection. This summary includes the complete licensed property description so that you can review and determine if this collection covers the topics, technology or transaction type that is relevant for your needs. The full report will include all relevant deal data such as the royalty base, agreement date, term description, royalty rates and other deal terms. For reference, here is a sample of a full IPSCIO curated royalty rate report: Sample Report
IPSCIO Record ID: 3467
Researchers have demonstrated that a deficiency of BH4 can disrupt NO synthesis, resulting in a loss of normal endothelial NO production. This loss of endothelial NO production, commonly referred to as endothelial dysfunction, has been associated with many cardiovascular diseases, including hypertension, diabetic vascular disease, peripheral arterial disease, coronary arterial disease and pulmonary hypertension, and has been shown to be a strong predictor of cardiovascular adverse events in a number of clinical studies.
IPSCIO Record ID: 29337
IPSCIO Record ID: 227277
Phenoptinâ„¢ is a proprietary oral form of tetrahydrobiopterin (6R-BH4), for the treatment of moderate to mild forms of phenylketonuria (PKU). PKU is a genetic disorder caused by a deficiency of an enzyme, phenylalanine hydroxylase (PAH), which is required for the metabolism of phenylalanine (Phe), an amino acid found in most protein-containing foods.
Phenylketonuria (commonly known as PKU) is a rare inherited disorder that increases the levels of a substance called phenylalanine in the blood. Phenylalanine is a building block of proteins (an amino acid) that is obtained through the diet. It is found in all proteins and in some artificial sweeteners. PKU is caused by a defect in the gene that helps create the enzyme needed to break down phenylalanine.
IPSCIO Record ID: 28042
IPSCIO Record ID: 2719
IPSCIO Record ID: 3248
AVAPRO/AVALIDE is an angiotensin II receptor blocker for the treatment of hypertension.
IPSCIO Record ID: 203326
Licensee expressly acknowledges that the license granted includes a sublicense of certain rights licensed to Licensor pursuant to the Existing Third Party Agreements, and any sublicense of such rights must comply with the requirements set forth in the respective Existing Third Party Agreements regarding sublicenses granted pursuant to such Existing Third Party Agreement.
The Licensed Product means any product incorporating Phenoptin or Phenylase as an active pharmaceutical ingredient, either alone or with one or more other pharmaceutical ingredients, including all additions, mutations, post-translational modifications (e.g., PEGylation), rearrangements, and other modifications thereto and any other pharmaceutical product that the manufacture, use, sale, offer to sell or import thereof, would infringe one or more Patent Claims under any Patents in or to any Licensor IP; or the research, development, formulation, composition or manufacture of which was performed with the use of or incorporates any Licensor IP; or the development of which was in part funded by Licensor under this Agreement. The term Licensed Product shall include Supplied Product.
Phenoptin means tetrahydrobiopterin (6R-BH4). Phenylase means phenylalanine ammonia lyase.
Licensors IP includes patents for Methods and Compositions for the Treatment of Phenylketonuria, Crystalline Forms of (6R)-L-erythro-tetrahydrtobiopterin dihydrochloride and Methods for Preparing Tetrahydrobiopterin, and others.
Phenylketonuria also called PKU, is a rare inherited disorder that causes an amino acid called phenylalanine to build up in the body. PKU is caused by a defect in the gene that helps create the enzyme needed to break down phenylalanine.
Without the enzyme necessary to process phenylalanine, a dangerous buildup can develop when a person with PKU eats foods that contain protein or eats aspartame, an artificial sweetener. This can eventually lead to serious health problems.
IPSCIO Record ID: 230780
'Existing Patents' means the RSD930 and RSD1236 Patent Families (ApplicationNumbers US 09/328,540; PCT/CA99/00535; US 09/328,541; PCT/CA99/00534; PCT/CA00/01506; PCT/CA00/01507; PCT/CA00/01508; PCT/CA98/00842 and Thailand Patent Appl.# 045858; Taiwan Patent Appl.# 87114395; The Philippines Patent Appl. # 98/2246; and Malaysia Patent Appl. # Pl 9804017 and all patentm applications claiming priority therefrom or sharing at least one common priority therewith).