Royalty Report: Drugs, Cancer, Pharmaceuticals – Collection: 33130

$150.00

Curated Royalty Rate Report
Created On: 2020-07-15, Record Count: 9

Description

This collection of transactions and supporting information was developed using our AI algorithm to curate similar royalty reports into a cohesive collection to support your licensing, transfer pricing or other transaction scenarios where documented royalty rates and/or deal terms are important.
Created On: 2020-07-15
Record Count: 9

Primary Industries

  • Drugs
  • Cancer
  • Pharmaceuticals
  • Disease
  • Biotechnology
  • Therapeutic
  • Diagnostic
  • Specialty

IPSCIO Report Record List

Below you will find the records curated into this collection.  This summary includes the complete licensed property description so that you can review and determine if this collection covers the topics, technology or transaction type that is relevant for your needs.  The full report will include all relevant deal data such as the royalty base, agreement date, term description, royalty rates and other deal terms.  For reference, here is a sample of a full IPSCIO curated royalty rate report: Sample Report

IPSCIO Record ID: 33130

License Grant
The Hong Kong Company entered into an agreement that grants to the Chinese Licensee an exclusive license to develop, manufacture and commercialize fruquintinib for all uses in China and Hong Kong.
License Property
Fruquintinib is a highly selective and potent oral inhibitor of the vascular endothelial growth factor receptor, or VEGFR, and consequently we believe it has the potential to be a global best-in-class VEGFR inhibitor for many types of solid tumors. Based on pre-clinical and clinical data to date, fruquintinibs kinase selectivity has been shown to reduce off-target toxicity. This allows for drug exposure that is able to fully inhibit VEGFR, a protein ligand which contributes to the growth of tumors, and use in potential combinations with other targeted therapies and chemotherapy in earlier lines of treatment with larger patient populations.
Field of Use
This agreement pertains to drugs in the medical industry. Fruquintinib is a targeted oncology therapy for the treatment of various types of solid tumors.

IPSCIO Record ID: 256505

License Grant
The 2018 Amendment covers adjustments in the respective roles and responsibilities of the Chinese parties, in China, for the development and commercialization of fruquintinib in the areas of future life cycle planning and development, collaborations for co-development of fruquintinib with other third-party anti-cancer agents as well as promotion and distribution rights of fruquintinib.  The 2018 Amendment now gives Licensor all planning, execution and decision making responsibilities for LCI development on fruquintinib in China.  The 2018 Amendment provides Licensor the right to promote fruquintinib in provinces that represent 30% of the sales of fruquintinib in China (“Licensor Territory”) upon the occurrence of certain commercial milestones.
License Property
Fruquintinib (brand name: Elunate®) is a small molecule, selective and highly potent inhibitor of VEGFR 1, 2 and 3. VEGFR inhibitors play a pivotal role in tumor-related angiogenesis, cutting off the blood supply that a tumor needs to grow rapidly.
Fruquintinib is an orally available, small molecule inhibitor of vascular endothelial growth factor receptors (VEGFRs), with potential anti-angiogenic and antineoplastic activities. Upon oral administration, fruquintinib inhibits VEGF-induced phosphorylation of VEGFRs 1, 2, and 3 which may result in the inhibition of migration, proliferation and survival of endothelial cells, microvessel formation, the inhibition of tumor cell proliferation, and tumor cell death. Expression of VEGFRs may be upregulated in a variety of tumor cell types.
Field of Use
Fruquintinib is under investigation for the treatment of NSCLC. Fruquintinib has been investigated for the treatment of ColoRectal Cancer.

IPSCIO Record ID: 4661

License Grant
The parties entered into an exclusive license agreement to develop and commercialize lucitanib on a global basis, excluding China.
License Property
Lucitanib is an oral, potent inhibitor of the tyrosine kinase activity of fibroblast growth factor receptors 1 through 3 (FGFR1-3), vascular endothelial growth factor receptors 1 through 3 (VEGFR1-3) and platelet-derived growth factor receptors alpha and beta (PDGFR α-ß).
Field of Use
A Phase I/IIa clinical trial of lucitanib was initiated in 2010 and has demonstrated multiple objective responses in FGFR1 gene-amplified breast cancer patients, and objective responses were also observed in patients with tumors often sensitive to VEGFR inhibitors, such as renal cell and thyroid cancer. FGFR amplification is common in a number of tumor types, including breast cancer and squamous non-small cell lung cancer, and we intend to study lucitanib in these cancers as well as other solid tumors exhibiting FGFR pathway activation.

IPSCIO Record ID: 35129

License Grant
The Hong Kong Company  granted a co-exclusive, worldwide rights to develop, and exclusive worldwide rights to manufacture and commercialize savolitinib for all diagnostic, prophylactic and therapeutic uses.
License Property
Savolitinib is a potential global first-in-class inhibitor of the mesenchymal epithelial transition factor, or c-Met, receptor tyrosine kinase, an enzyme which has been shown to function abnormally in many types of solid tumors. We developed savolitinib as a potent and highly selective oral inhibitor that was designed to address renal toxicity, the primary issue that has prevented all other selective c-Met inhibitors from gaining regulatory approval. In Phase I clinical studies, savolitinib has shown promising signs of clinical efficacy, causing tumor size reduction in patients with c-Met gene amplification in papillary renal cell carcinoma, non-small cell lung cancer, colorectal cancer and gastric cancer.
Field of Use
This agreement pertains to drugs for all diagnostic, prophylactic and therapeutic uses in the medical industry.

IPSCIO Record ID: 284140

License Grant
Licensor granted Licensee worldwide exclusive development and commercialization rights to capmatinib and certain back-up compounds in all indications.
License Property
Capmatinib is a potent and highly selective MET inhibitor. The investigational compound has demonstrated inhibitory activity in cell-based biochemical and functional assays that measure MET signaling and MET dependent cell proliferation, survival and migration.
c-Met inhibitors are a class of small molecules that inhibit the enzymatic activity of the c-Met tyrosine kinase, the receptor of hepatocyte growth factor/scatter factor (HGF/SF). These inhibitors may have therapeutic application in the treatment of various types of cancers.
Field of Use
Capmatinib is being evaluated in patients with hepatocellular carcinoma, non-small cell lung cancer and other solid tumors, and may have potential utility as a combination agent.

IPSCIO Record ID: 241600

License Grant
The Licensor grants to the Cayman Islands Licensee an exclusive royalty-bearing, non-sublicensable, non-transferable license under the Licensor Technology and interest in the Joint Combination Therapy Technology to Commercialize Licensed Products in the Field in the Territory.
License Property
Technology relates to he oral inhibitor enzyme is Ivosidenib for the treatment of hematologic and solid tumor indications.  Ivosidenib is an investigational, first-in-class, oral, targeted inhibitor of the mutant isocitrate dehydrogenase-1 (IDH1) enzyme.

Ivosidenib is an investigational first-in-class, orally available, selective, potent inhibitor of the mutated IDH1 protein and is a highly targeted investigational medicine for the treatment of patients with cancers that harbor an IDH1 mutation. IDH1 is a metabolic enzyme that is mutated in a wide range of cancers, including acute myeloid leukemia, cholangiocarcinoma and glioma. Ivosidenib is currently under U.S. FDA priority review for IDH1m R/R AML patients with a PDUFA action date of August 21, 2018.

Field of Use
Licensee has expertise in the development of biopharmaceutical products and will be responsible for conducting the development and commercialization activities for ivosidenib in hematologic and solid tumor indications.

IPSCIO Record ID: 183924

License Grant
The China based Licensor and Licensee of Sweden enter the amendment to the joint development agreement is for the global pivotal Phase III study in c-Met-driven PRCC. The original agreement is co-exclusive.
License Property
Savolitinib is an inhibitor of c-Met, an enzyme which has been shown to function abnormally in many types of solid tumors.  It is designed to be a potent and highly selective oral inhibitor, which through chemical structure modification addressed human metabolite-related renal toxicity, the primary issue that halted development on several other selective c-Met inhibitors.
Field of Use
Phase III clinical trial is related to developing savolitinib for papillary renal cell carcinoma.

IPSCIO Record ID: 243413

License Grant
Licensor grants an exclusive, worldwide license to Licensors entire interest in and to Licensed Patents within the Field to make, have made, use, import, have imported, sell, offer for sale and otherwise exploit and distribute Licensed Products, and,  practice any method, process or procedure included within the Licensed Patents; and to have any of the foregoing performed on its behalf by a third party.
License Property
The patents are for Vascular Targeting Agents and targeting vascular endothelial growth factor or VEGF.

The VTA technology is a proprietary therapeutic platform designed to specifically target tumor vasculature and subsequently destroy the tumor with various attached therapeutic agents.

Field of Use
Field shall mean vascular endothelial growth factor (VEGF), in the native, mutants and variants thereof, conjugated to cytotoxic drugs, toxins, radionuclides or photodynamic therapy agents for targeting tumors and cells expressing VEGF receptors and tumor blood vessels for therapy of cancer and blood vessel proliferative disorders, including but not limited to macular degeneration, diabetic retinopathy, and pannus formation.

IPSCIO Record ID: 2250

License Grant
The VTA technology was acquired in April of 1997 through the Licensee's acquisition of the Licensor's Phase I Study.  The Licensee has entered into several license agreements in order to acquire all of the rights which it deems necessary to proceed with its vascular targeting agent ('VTA's') technology.
License Property
VTA’s act by destroying the vasculature of solid tumors.  VTA’s are multifunctional molecules that target the capillaries and blood vessels of solid tumors. Once there, these agents block the flow of oxygen and nutrients to the underlying tissue by creating a blood clot to the tumor.  Within hours of the clots formation, the tumor begins to die and necrotic regions are formed.  Since every tumor in excess of 2mm in size forms an expanding vascular network during tumor growth, VTA’s could be effective against all types of solid tumors.
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