Description
Category: Technology Licenses
Created On: 2022-04-28
Record Count: 14
Primary Industries
- Cancer
- Drugs
- Diagnostic
- Drug Discovery
- Drug delivery
- Pharmaceuticals
- Disease
- Medical
- Biotechnology
- Vaccine
- Genome
- Test/Monitoring
- Therapeutic
IPSCIO Report Record List
Below you will find the records curated into this collection. This summary includes the complete licensed property description so that you can review and determine if this collection covers the topics, technology or transaction type that is relevant for your needs. The full report will include all relevant deal data such as the royalty base, agreement date, term description, royalty rates and other deal terms. For reference, here is a sample of a full IPSCIO curated royalty rate report: Sample Report
IPSCIO Record ID: 328128
Field shall mean use or intended for use in the diagnosis and/or prognosis of cancer, and/or for the medical management of cancer, including without limitation the determination (whether by selection or exclusion) of a particular intervention for the prevention and/or treatment of cancer, in humans, including without limitation the use of specific reagents, kits or diagnostic devices.
IPSCIO Record ID: 330686
Also included is a grant back If this Licensor desires to develop, manufacture, exploit, import, use, offer for sale or sell any Companion Diagnostic on its own or with or through any Affiliate or Third Party, it will send written notice thereof to Licensee, and, if Licensee chooses not to develop, then Licensor shall be granted any associated rights to do so.
Companion Diagnostics means any diagnostic product or biomarker arising from work performed by Licensor pursuant to the terms of this Agreement or otherwise derived from or based in whole or in part on Licensees Intellectual Property.
Discovery Product means a pre-clinical Licensed Product identified through a Screening Assay which possesses desirable properties of a therapeutic or prophylactic agent for the treatment of a clinical condition based on in vitro studies.
Therapeutic Product means an agent with prophylactic or therapeutic activity for the prevention and/or treatment of cancer, developed, in whole or in part, from a Discovery Product and intended to be used, or is used, to treat cancer in humans.
Licensee Patent Rights include
– FGFR1/2 IIIc in NSCLC resistant to erlotinib.
– FGFRviii in glioblastoma.
MIT Patent Rights include
– Alternatively Spliced mRNA lsoforms as Prognostic Indicators for Metastatic Cancer.
Licensees therapeutic focus targets a critical metastatic pathway in solid tumors responsible for driving tumor resistance and the spread of aggressive cancer.
IPSCIO Record ID: 369296
(A) United States of America Provisional Application Serial No. 61/446,162, Filed February 24, 2011
“Alternatively Spliced mRNA Isoforms as Prognostic and Therapeutic Tools for Metastatic Breast Cancer and Other Invasive/Metastatic Cancersâ€
by Christopher B. Burge, Wu Albert. Cheng, John Condeelis, Frank B. Gertler, Maja Oktay and Irina M. Shapiro
(B) United States of America Provisional Application No. 61/498,387, Filed June 17, 2011
“Alternatively Spliced mRNA Isoforms as Prognostic and Therapeutic Tools for Metastatic Breast Cancer and Other Invasive/Metastatic Cancersâ€
by Christopher B. Burge, Wu Albert. Cheng, John Condeelis, Frank B. Gertler, Maja Oktay and Irina M. Shapiro
(C) United States of America Serial No. 14/000995, Filed August 22, 2013
“Alternatively Spliced mRNA Isoforms As Prognostic Indicators For Metastatic Cancerâ€
by Christopher B. Burge, Wu Albert. Cheng, John Condeelis, Frank B. Gertler, Maja Oktay and Irina M. Shapiro
Discovery Product shall mean a pre-clinical Licensed Product identified through a Screening Assay which possesses desirable properties of a therapeutic or prophylactic agent for the treatment of a clinical condition based on in vitro studies.
Screening Assay shall mean the use of Licensed Product or Licensed Process for drug screening and drug discovery for small molecules (e.g., a small organic molecule, nucleic acid, or peptide).
Therapeutic Product shall mean an agent with prophylactic or therapeutic activity for the prevention and/or treatment of cancer, developed, in whole or in part, from a Discovery Product and intended to be used, or is used, to treat cancer in humans.
IPSCIO Record ID: 328126
– an exclusive right and license in the Field to all of Licensors Intellectual Property, other than the MIT Patent Rights, solely to develop, manufacture, exploit, import, use, offer for sale and sell Licensed Product and Licensed Process into and throughout the Territory;
– an exclusive right and sublicense to all of Licensors rights to the MIT Patent Rights under the Therapeutic License Agreement, subject to the Retained Rights, as that term is defined in the Therapeutic License Agreement as of the Effective Date, to develop, manufacture, exploit, import, use, offer for sale and sell Licensed Product and Licensed Process in the Field for use in the Territory; and
– a non-exclusive license to all of Licensors Intellectual Property for research and development of Companion Diagnostics.
If at any time Licensee desires to develop, manufacture, exploit, import, use, offer for sale or sell any Companion Diagnostic on its own or with or through any Affiliate or Third Party, it will send written notice thereof to Licensor, and, if Licensor chooses not to develop, then Licensee shall be granted the rights to do so.
The licensed technology includes (I) Alternative Splicing Event (ASE) technology based on International Patent Application WO 2012/116248 A1 entitled 'Alternatively Spliced mRNA Isoforms as Prognostic and Therapeutic Tools for Metastatic Breast Cancer and Other Invasive/Metastatic Cancers'; and (ii) Technology and know-how stemming.
Companion Diagnostics means any diagnostic product or biomarker arising from work performed by Licensee pursuant to the terms of this Agreement or otherwise derived from or based in whole or in part on Licensors Intellectual Property.
Discovery Product means a pre-clinical Licensed Product identified through a Screening Assay which possesses desirable properties of a therapeutic or prophylactic agent for the treatment of a clinical condition based on in vitro studies.
Licensor Patent Rights include
– FGFR1/2 IIIc in NSCLC resistant to erlotinib.
– FGFRviii in glioblastoma.
MIT Patent Rights include
– Alternatively Spliced mRNA lsoforms as Prognostic Indicators for Metastatic Cancer.
Licensee is a precision oncology medicine company pioneering the discovery and development of small molecule, tumor-agnostic therapies.
IPSCIO Record ID: 4559
IPSCIO Record ID: 4557
Licensee shall have the right to grant a Sublicense to the Tangible Property.
The Licensee develops and commercializes novel diagnostic technologies and therapeutics for the early and reliable prediction and treatment of systemic metastasis – cancer that spreads from a primary tumor through the bloodstream to other areas of the body.
IPSCIO Record ID: 263930
–Method for Screening Libraries of Enzymes with Improved Catalytic Properties or Altered Substrate Specificity Using Microwells for the Spatial Separation of Cells Producing the Enzymes;
–Method for Diagnosing Allergic Reactions;
–Method for Detecting Active and Latent Virally Infected Cells;
–Method for Assessing Cytotoxicity of Single Cells;
–Composition of an Array of Microwells with an Integrated Microfluidic System; and,
–Screening Assays and Methods.
The Apparatus Product shall mean a Licensed Product that is a microarray comprising microwells.
The Diagnostic Product shall mean a Licensed Product or Discovered Product that is used or intended for use in the diagnosis and/or prognosis of diseases or conditions, and/or for the medical management of disease or conditions, including without limitation the determination of a particular intervention for the prevention and/or treatment of disease, in humans, including without limitation application specific reagents and kits.
The Therapeutic Product shall mean a Licensed Product or Discovered Product that is used or intended for use in the treatment and/or prevention of human disease, including, without limitation, therapeutic and prophylactic vaccines.
The Veterinary product shall mean a Licensed product or Discovered product that is used or intended for use in the diagnosis and/or prognosis of disease in non-human animals, and/or the determination of a particular intervention for the prevention and/or treatment of disease, including without limitation application specific reagents and kits, and/or the treatment and/or prevention of disease in non-human animals, including without limitation therapeutic and prophylactic vaccines.
IPSCIO Record ID: 328124
The patents include Isolation, Gene Expression, And Chemotherapeutic Resistance Of Motile Cancer Cells, and, Human Invasion Signature For Prognosis Of Metastatic Risk.
The intellectual property covered by the Second License Agreement are summarized as follows
1.
U.S. Patent Application No. 11/659,514 entitled “Isolation, Gene Expression, And Chemotherapeutic Resistance Of Motile Cancer Cellsâ€
2.
Canadian Patent Application No. 2,576,702 entitled “Isolation, Gene Expression, And Chemotherapeutic Resistance Of Motile Cancer Cellsâ€
3.
European Patent Application No. 05807467.5 entitled “Isolation, Gene Expression, And Chemotherapeutic Resistance Of Motile Cancer Cellsâ€
4.
U.S. Provisional Patent Application (pending) entitled “Human Invasion Signature For Prognosis Of Metastatic Riskâ€
The intellectual property covered by the Third License Agreement are summarized as follows
1.
U.S. Patent Application No. 12/998,237 (based on PCT International Patent Application No. PCT/2009/005851) entitled “An In Vivo Quantitative Screening Test For Anti-Metastasis Treatment Efficacyâ€
The Therapeutic Field means products and services for therapeutic use.
IPSCIO Record ID: 344534
Licensor grants a non- exclusive sublicense under Technology Rights to manufacture, have manufactured, distribute, have distributed, use, offer for Sale, Sell, lease, loan and/or import Licensed Products in the Field of Use in the Territory and to perform Licensed Services in the Field of Use in the Territory.
The patents include
MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Solid Cancers
Compositions and Methods for the Diagnosis and Therapy of BCL2-Associated Cancers
MicroRNA Based Methods and Compositions for the Diagnosis and Treatment of Colon Related Diseases
Ultraconserved Regions Encoding ncRNAs
Methods for Identifying Fragile Histidine Triad (Fhit) Interaction and Uses Thereof
Materials and Methods Related to Modulation of Mismatch Repair and Genomic Stability by miR-155
Materials and Methods Related to MicroRNA-21. Mismatch Repair, And Colorectal Cancer
Mutator activity induced by microRNA-155 (miR-155) Links Inflammation and Cancer
Methods and Compositions Related to miR-21 & miR-29a and Cancer Metastasis
Mechanism of NSAID Chemoprevention in Colorectal Cancer
Licensed Product means any product, apparatus, kit, test having a panel of either a single nucleotide or two or more nucleotides in combination or component thereof whose manufacture, use, sale, offer for sale or import is Covered By any claim or claims included within the Patent Rights or incorporates any Technology Rights, or which is made using a Licensed Process or another Licensed Product.
IPSCIO Record ID: 299285
IPSCIO Record ID: 4690
IPSCIO Record ID: 372423
University grants a non-exclusive sublicense under Technology Rights to manufacture, have manufactured, distribute, have distributed, use, offer for Sale, Sell, lease, loan and/or import Licensed Products in the Field of Use in the Territory and to perform Licensed Services in the Field of Use in the Territory.
– MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Solid Cancers;
– Compositions and Methods for the Diagnosis and Therapy of BCL2-Associated Cancers;
– MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Prostate Related Disorders;
– Ultraconserved Regions Encoding ncRNAs; and,
– Materials and Methods Related to Modulation of Mismatch Repair and Genomic Stability by miR-155.
Licensed Product means any product, apparatus, kit, test having a panel of either a single nucleotide or two or more nucleotides in combination or component thereof whose manufacture, use, sale, offer for sale or import is Covered By any claim or claims included within the Patent Rights or incorporates any Technology Rights, or which is made using a Licensed Process or another Licensed Product.
IPSCIO Record ID: 3479
U.S. Provisional Patent Application No. 61/276,263, entitled 'Tumor Microenvironment of Metastasis (TMEM)
Cell Line means a hybridoma cell line that produces Anti-pan Mena murine monoclonal antibodies.
Materials means anti-pan Mena murine monoclonal antibodies produced by the Cell Line.
Diagnostic Field means products and services for diagnostic use.
Therapeutic Field means products and services for therapeutic use.
U.S. Patent Application No. 12/462,324, entitled 'Metastasis specific splice variants of Mena and uses thereof in diagnosis, prognosis and treatment of tumors'
U.S. Continuation-in-part of PCT/US08/1343, entitled 'Metastasis specific splice variants of Mena and uses thereof in diagnosis, prognosis and treatment of tumors'
In return, the Licensee has agreed to grant equity to Licensors, to reimburse Licensors patent expenses thus far incurred, to pay all future patent expenses, pay a royalty on any sales of product using Licensed technology, as well as certain minimum royalties and milestone payments.
IPSCIO Record ID: 344535
Licensor grants a non- exclusive sublicense under Technology Rights to manufacture, have manufactured, distribute, have distributed, use, offer for Sale, Sell, lease, loan and/or import Licensed Products in the Field of Use in the Territory and to perform Licensed Services in the Field of Use in the Territory.
Patents include
MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Solid Cancers,
MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis, and Treatment of Lung Cancer,
Material and Methods Useful for Affecting Tumor Cell Growth, Migration, and Invasion,
Ultraconserved Regions Encoding ncRNAs,
Materials and Methods Related to Modulation of Mismatch Repair and Genomic Stability by miR-155,
Methods for Reverting Methylation by Targeting DNMT3A and DNMT3B,
Methods of Identifying Fragile Histidine Triad (FHIT) Interaction and Uses Thereof,
Methods and Compositions Related to miR-21 and miR-29a, Exosome Inhibition and Cancer Mestastsis,
miRNAs Useful to Reduce Lung Cancer Turmorigenesis and Chemotherpay Resistance and Related Compositions and Methods,
Mutator Activity Induced by microRNA-155 (miR-155) Links Inflammation and Cancer, and,
Use of miR-494 to Modulate TRAIL-induced Apoptosis through BIM Down-regulation.
Licensed Product means any product, apparatus, kit, test having a panel of either a single nucleotide or two or more nucleotides in combination or component thereof whose manufacture, use, sale, offer for sale or import is Covered By any claim or claims included within the Patent Rights or incorporates any Technology Rights, or which is made using a Licensed Process or another Licensed Product.
