Royalty Report: Diagnostic, DNA, Drugs – Collection: 233466

$150.00

Curated Royalty Rate Report
Category: Technology Licenses, Created On: 2022-04-28, Record Count: 16

Description

This collection of transactions and supporting information was developed using our AI algorithm to curate similar royalty reports into a cohesive collection to support your licensing, transfer pricing or other transaction scenarios where documented royalty rates and/or deal terms are important.
Category: Technology Licenses
Created On: 2022-04-28
Record Count: 16

Primary Industries

  • Diagnostic
  • DNA
  • Drugs
  • Medical
  • Drug Discovery
  • Cancer
  • Medical Info
  • Therapeutic
  • Disease
  • Scientific & Technical Instruments
  • Molecular
  • Device
  • HIV / AIDs
  • Assay
  • Surgical
  • Genome
  • ribonucleic acid
  • Software
  • nucleic acid

IPSCIO Report Record List

Below you will find the records curated into this collection.  This summary includes the complete licensed property description so that you can review and determine if this collection covers the topics, technology or transaction type that is relevant for your needs.  The full report will include all relevant deal data such as the royalty base, agreement date, term description, royalty rates and other deal terms.  For reference, here is a sample of a full IPSCIO curated royalty rate report: Sample Report

IPSCIO Record ID: 233466

License Grant
This Agreement is to allow the Licensee to exclusively develop and market products based on the Licensed Technology within the Exclusive Field.

Licensor hereby grants to Licensee a Semi-Exclusive, royalty-bearing license, including the right to grant sublicenses, under the Licensed Patent Rights and under all of Licensor’s right, title and interest in and to the Licensed Technology and Improvements, to make, have made, use, have used, sell, offer for sale, have sold, import, and have imported Licensed Products and to perform and have performed Licensed Services in the Territory.

Semi-Exclusive shall mean that the license granted herein to Licensee shall be exclusive, even as pertaining to Licensor, within the Field, provided, however, that Licensor hereby retains the right to perform activities within the Co-Exclusive Field without the right to grant further licenses or sublicenses within the Co-Exclusive Field.

License Property
The Licensed Technology shall mean and include all Technology, whether or not patentable, that is useful for the performance of Sequencing by Synthesis (SBS) within the Field and that is Controlled by Licensor as of the Effective Date. Licensed Technology specifically does not include any biomarkers (content) Licensor has identified utilizing SBS and other technologies for generation of sequence information, when not used in association with SBS, such as capillary electrophoresis, mass spectrometry and sequencing by hybridization.

Sequencing by Synthesis or SBS shall mean Licensors proprietary process for determining the sequence of genetic material by synthesizing from a template derived from such material.

Licensors Kit shall mean all reagents, equipment, components, kits and instructions for preparation and operation that are necessary and sufficient for Licensee to sequence a sample.

Hardware Products shall mean Licensed Products that consist of hardware or instruments used in SBS, but excluding any such hardware or instruments that are used for Sample Preparation or instruments used for assemblies or analysis of sequence information, for example computer processing units.

Licensed Product shall mean any product, the manufacture, use, sale of which would, absent the license granted to Licensee hereunder, infringe any Valid Claim included in the Licensed Patent Rights.

Licensed Services shall mean any service performed by Licensee for a Third Party, the performance of which would, absent the license granted to Licensee hereunder, infringe any Valid Claim included in the Licensed Patent Rights.

Reagent Products shall mean Licensed Products that consist of reagents that are used to perform SBS excluding any kits, reagents or components that are used for Sample Preparation and excluding any hardware or instruments.

Field of Use
Co-exclusive field shall mean sequencing applications performing between 10,000 to 50,000 different DNA sequencing reactions in one process cycle, including but not limited to, with respect to any or all organisms and for whatever purpose or purposes, a) sequencing all or essentially all, of a genome, genomic region, or chromosome based on sequencing, b) expression profiling based on cDNA/mRNA sequencing, c) repetitive sequencing of genomic regions or specific cDNA, and, d) performing SNP analyses of whole genomes or between 10000 to 50000 where the license is non-exclusive under this agreement.

Exclusive Field shall mean sequencing applications performing between 10000 to 50000 different DNA sequencing in one  process cycle, including but not limited to, with respect to any or all organisms and for whatever purpose or purposes, a) sequencing all or essentially all, of a genome, genomic region, or chromosome based on sequencing, b) expression profiling based on cDNA/mRNA sequencing, c) repetitive sequencing of genomic regions or specific cDNA, and, d) performing SNP analyses of whole genomes or more than 50000 in one process cycle.

Field shall mean sequencing applications performing more than 10000 different DNA sequencing in one  process cycle, including but not limited to, with respect to any or all organisms and for whatever purpose or purposes, a) sequencing all or essentially all, of a genome, genomic region, or chromosome based on sequencing, b) expression profiling based on cDNA/mRNA sequencing, c) repetitive sequencing of genomic regions or specific cDNA, and, d) performing SNP analyses of whole genomes or more than 10000 in one process cycle.

IPSCIO Record ID: 240568

License Grant
Licensor hereby grants to the Japanese Licensee and its Affiliates an exclusive royalty-bearing license under Patent Rights and Licensee Know-How, without rights to sublicense, to use Megaclone(TM) technology to provide MPSS(TM) Services and Megasort(TM) Services to customers in the Territory and to make and sell Microarrays containing nucleic acid sequences identified by Megasort(TM) or MPSS(TM) technologies to customers in the Territory, whether or not such nucleic acid sequences were known or described prior to such identification. From and after the fifth anniversary of the Effective Date or upon failure to satisfy the Performance Criteria, whichever occurs sooner, the license rights of this paragraph shall become non-exclusive for the remainder of the term of the Agreement.

Licensor hereby grants to Licensee a worldwide non-exclusive license, without a right to sublicense, to use the trademarks and service marks 'LYNX,' 'MEGACLONE,' 'MPSS,' and 'MEGASORT' (collectively, the 'Licensed Marks') in advertising and other promotional materials related to the use of Licensor Technology hereunder and in packaging, advertising and other promotional materials related to the sale, distribution, and marketing of Microarrays containing nucleic acid sequences identified by Megasort(TM) or MPSS(TM) technologies.

License Property
Megaclone(TM) technology means the technology owned and/or controlled by Licensor for generating a population of microbeads having complementary DNA (cDNA) molecules attached wherein substantially every different cDNA molecule is attached to a different microbead of the population.

A Megaclone(TM) Library means a cDNA library which has been transformed using Megaclone(TM) technology into a population of microbeads each having attached a clonal population of a distinct cDNA molecule. As used herein, Megaclone(TM) technology does not include any process for attaching genomic fragments of DNA to microbeads or any other solid phase support.

Megasort(TM) Service means the analysis of genes expressed in different cell or tissue sources by Megasort(TM) technology.

Megasort(TM) technology means the technology owned and/or controlled by Licensor for detecting and isolating gene products, such as cDNA molecules, differentially expressed in two different cell or tissue sources by fluorescence activated cell sorting (FACS) analysis of a Megaclone(TM) Library to which differently labeled probes derived from the two different cell or tissue sources have been competitively hybridized.

Microarray means a solid phase support containing a plurality of discrete regions such that within each discrete region a single species of nucleic acid is attached. Said nucleic acid may be attached covalently or non-covalently by any method, including, but not limited to, deposition of a solution containing a separately synthesized cDNA, polynucleotide, or oligonucleotide, or in situ synthesis using ink-jet, photolithographic, or any other chemical technologies.

Microarray Spot means a discrete region of a Microarray in which a single species of nucleic acid is attached.

MPSS(TM) Service means the analysis of genes expressed in a cell or tissue by MPSS(TM) technology.

MPSS(TM) technology means the technology owned and/or controlled by Licensor for simultaneously generating signature sequences of cDNAs in a Megaclone(TM) Library disposed in a flow cell using the ligation-based sequencing method described in Brenner et al, Nature Biotechnology.

MPSS(TM) Instrument means an apparatus for carrying out the process steps of MPSS(TM) technology. An MPSS(TM) Instrument consists of the following modules Flow Cell including housing with heating and cooling system, optical/imaging system, fluid delivery system, control/monitoring system, and data collection software.

5,552,278 – DNA sequencing by stepwise ligation and cleavage
5,856,093 – Method of determining zygosity by ligation and cleavage
5,831,065 – Kits for DNA sequencing by stepwise ligation and cleavage

Field of Use
This agreement pertains to genetic analysis.

IPSCIO Record ID: 329706

License Grant
Subject to satisfaction of the Performance Criteria and for a period of five (5) years beginning from the Effective Date of the Agreement ('Period of Exclusivity'), Licensor hereby grants to Japanese  Licensee and its Affiliates an exclusive royalty-bearing license under Patent Rights and Licensor Know-How, without rights to sublicense, to use Megaclone(TM) technology to provide MPSS(TM) Services and Megasort(TM) Services to customers in the Territory and to make and sell Microarrays containing nucleic acid sequences identified by Megasort(TM) or MPSS(TM) technologies to customers in the Territory, whether or not such nucleic acid sequences were known or described prior to such identification. From and after the fifth anniversary of the Effective Date or upon failure to satisfy the Performance Criteria or whichever occurs sooner, the license rights of this paragraph shall become non-exclusive for the remainder of the term of the Agreement.
License Property
U.S. Patent #5,552,278 – DNA sequencing by stepwise ligation and cleavage
U.S. Patent #5,856,093 – Method of determining zygosity by ligation and cleavage
U.S. Patent #5,831,065 – Kits for DNA sequencing by stepwise ligation and cleavage

Megaclone(TM) technology means the technology owned and/or controlled by Licensor for generating a population of microbeads having complementary DNA (cDNA) molecules attached wherein substantially every different cDNA molecule is attached to a different microbead of the population. A 'Megaclone(TM) Library' means a cDNA library which has been transformed using Megaclone(TM) technology into a population of microbeads each having attached a clonal population of a distinct cDNA molecule. As used herein, Megaclone(TM) technology does not include any process for attaching genomic fragments of DNA to microbeads or any other solid phase support.

MPSS(TM) Service means the analysis of genes expressed in a cell or tissue by MPSS(TM) technology.

MPSS(TM) technology means the technology owned and/or controlled by Licensor for simultaneously generating signature sequences of cDNAs in a Megaclone(TM) Library disposed in a flow cell using the ligation-based sequencing method described in Brenner et al, Nature Biotechnology, 18 630-634 (2000).

Megasort(TM) Service means the analysis of genes expressed in different cell or tissue sources by Megasort(TM) technology.

Megasort(TM) technology means the technology owned and/or controlled by Licensor for detecting and isolating gene products, such as cDNA molecules, differentially expressed in two different cell or tissue sources by fluorescence activated cell sorting (FACS) analysis of a Megaclone(TM) Library to which differently labeled probes derived from the two different cell or tissue sources have been competitively hybridized.

Microarray means a solid phase support containing a plurality of discrete regions such that within each discrete region a single species of nucleic acid is attached. Said nucleic acid may be attached covalently or non-covalently by any method, including, but not limited to, deposition of a solution containing a separately synthesized cDNA, polynucleotide, or oligonucleotide, or in situ synthesis using ink-jet, photolithographic, or any other chemical technologies.

Field of Use
Field of use is for genetic analysis, including Megaclone(TM) technology for generating libraries of microbeads each containing a clone of a distinct DNA molecule, Megasort(TM) technology for isolating genes carried on Megaclone(TM) microbeads that are differentially expressed in two different cell or tissue sources, and MPSS(TM) technology for simultaneously generating signature sequences of DNA molecules carried on Megaclone(TM) microbeads.

IPSCIO Record ID: 230804

License Grant
Licensor grants a perpetual, exclusive, even as to Licensor, worldwide license or sublicense, with the right to grant sublicenses, under Licensor’s interest in the Core Technology, any Licensor Process Improvements and any Licensor Third Party Process Improvements to make, have made, use, sell, have sold, import, and have imported Instruments, Reagents and Software and to provide Sequencing Services, in any case solely within the Licensee Field and to otherwise exploit the Core Technology, Licensor Process Improvements and such Licensor Third Party Process Improvements, in each case for all purposes solely within the Licensee Field.
License Property
The patents and technology are for Novel Sequencing Methods and Pyrophosphate Sequencing.

Instrument means any device, equipment or instrument covered by a claim under the Core Patent Rights which is used to conduct DNA sequencing and/or analyze the results of such DNA sequencing, including, without limitation, the correlation of gene sequence expression and variation with disease, drug response or prognosis.

Royalty Bearing Services means the provision by Licensee to any Third Party of any service using instruments, including without limitation Sequencing Services.

Sequencing Services means the use of Instruments to characterize DNA sequences, measure RNA expression levels and/or karotype samples.

Reagents means any chemical compound or mixture of chemical compounds covered by a claim under the Core Patent Rights developed for use in an Instrument.

Software means any computer programs and software covered by a claim under the Core Patent Rights developed for use on an Instrument, including any upgrades, modifications and enhancements made for such programs and software. For purposes of this Agreement the term Software shall not indicate Licensor Proprietary Software.

Field of Use
The Licensee field is the design, development, manufacture, production, testing and sale of instruments, Reagents and Software for DNA sequencing and DNA-based analyses, and the aggregation of data obtained from third parties through the use of such instrumentation, to create either an internet portal or database for the sole purpose of generating sales of additional Instruments and sales of Reagents and Software for DNA-based analysis, and, the providing of sequencing services for any and all uses outside of the Licensor field and inside the Licensor field with prior Licensor approval.

IPSCIO Record ID: 233461

License Grant
The Swiss Licensor grants a non-exclusive license under the Licensed Patents as follows
– to make, have made, import, use, offer to Sell and Sell Licensed Products in the In Vitro Human Diagnostics Field in the Territory, and authorize End-Users to perform Diagnostic Services using such Licensed Products in processes covered by the Licensed Patents in accordance with the label license provided with the purchase of such Licensed Products.
– to grant a limited, non-transferable, royalty free sublicense under the Licensed Patents to Research Collaborators of Licensee and/or its Affiliates to practice PCR under their respective contracts with Licensee and/or its Affiliates, in accordance with the terms and conditions of this Agreement, solely for purposes of doing applied research and development for Licensee and/or its Affiliates of Licensed Products to be Sold in the In Vitro Human Diagnostics Field in accordance with the other terms and conditions of this Agreement; and
– to use PCR technology for the research, development, improvement and quality control and quality assurance of Licensed Products, in each case by Licensee and its Affiliates, internally, for Sale in the In Vitro Human Diagnostics Field.

For Label Licenses on Licensed Products Sold in the In Vitro Human Diagnostics
– Licensees right to sublicense is limited to the right to convey use rights pursuant to a Label License under process claims and composition of matter claims,not apparatus, device or system claims, only to End-User customers, and only through the Sale of Licensed Products.
– Licensee agrees that it shall mark conspicuously all Complete Diagnostic Kits made by or for it,
– Licensee agrees that it shall mark conspicuously all Component Systems for amplification made by or for it
– Licensee agrees that it shall mark conspicuously all Component Systems for detection made by or for it
– Licensee agrees that it shall mark conspicuously all Component Systems for amplification and detection made by or for it
– Licensee agrees that it shall mark conspicuously all Royalty Products other than Complete Diagnostic Kits, Component Systems for amplification, Component Systems for detection and Component Systems for amplification and detection made by or for it and Sold in the In Vitro Human Diagnostics Field.

License Property
The Complete Diagnostic Kit means a product dedicated for use in connection with the practice of PCR in the In Vitro Human Diagnostics Field, it being understood that a product shall be deemed to be so dedicated if it is either  a product having a package insert indicating its use primarily in connection with the practice of PCR; or a product which by virtue of its design, operation or construction has no other substantial practical utility, and which product is comprised of, at a minimum, the essential active reagents for amplification and detection of a target nucleic acid in the In Vitro Human Diagnostics Field. For purposes of this Agreement, Licensee shall only convey the necessary rights for End-Users to perform PCR in the In Vitro Human Diagnostics Field with the Sale of a Complete Diagnostic Kit.

Licensed Product means a product for use in the In Vitro Human Diagnostics Field, the manufacture, importation, use, offer for Sale or Sale of which would infringe a Valid Claim of Licensed Patents, made by or specifically for Licensee or any of its Affiliates only pursuant to Licensees or its Affiliates specifications, which is any of the following or a combination of any of the following
(a) Complete Diagnostic Kit;
(b) A reagent, accessory, device or system which is used or Sold to be used by End-Users in connection with the practice of PCR, including the steps of sample preparation, amplification and detection;
(c) A Component System; and/or
(d) Reagents Sold to be used by End-Users as replacement components in regard to a Component System.

PCR means the polymerase chain reaction process and technology.

Patents relate to Process for Amplifying, Detecting, and/or Cloning Nucleic Acid Sequences.

Field of Use
This agreement is for the purpose of developing and commercializing PCR based in vitro human diagnostic products for use in clinical diagnostic testing;

The Human Identity Field means the field of use comprising products and processes utilizing PCR for the sole purpose of determining human identity or distinguishing among human beings, whether living or dead. The Term Human Identity Field shall included parentage testing to determine if two or more human beings are biologically related as parent and child and forensic testing for use in, or in preparation for, death investigations or other legal proceedings, but such term shall specifically exclude testing for tissue typing.

In Vitro Human Diagnostics Field means the field of use comprising products and processes utilizing PCR for the measurement, observation or determination of attributes, characteristics, diseases, traits or other conditions of a human being for the medical management of that human being, including without limitation
(a) genetic testing, including determinations of genetic predisposition;
(b) oncology and cancer predisposition testing;
(c) testing for tissue typing (excluding the Human Identity Field);
(d) infectious disease detection, screening, confirmation and monitoring; and
(e) therapeutic drug monitoring.

For purposes of this Agreement, the term 'In Vitro Human Diagnostics Field' shall not include the Human Identity Field.

“PCR” means the polymerase chain reaction process and technology involving the amplification of a nucleic acid sequence and the complement of that sequence by repeated cycles of oligonucleotide mediated, template directed synthesis involving the extension of a component primer oligonucleotide by incorporation of monomeric nucleotide triphosphates whereby the sequence, its complement and subsequent synthetic copies thereof are repeatedly separated and used as templates for further cycles of synthesis.

IPSCIO Record ID: 210375

License Grant
Pursuant to this License agreement between the Licensee and a Swiss third party, is the right to use a license for intellectual property exclusively licensed to this Licensor by the third party.   A license under the Amplification Patent Rights for automated performance of the PCR Process in the Research Field based on the capacity of thermal cyclers used, and a running-royalty component for each use of the process.  In consideration of Licensees payment of the license issuance fee and of royalties on sales of Licensed Research Products, the Third Party grants to Licensee, in the Territory, limited, nonexclusive rights, without the right to sublicense except to its current Affiliates
a)     Licensee is hereby authorized to sell, strictly under Licensees or it Affiliates own Trademarks, Tradenames and/or label(s), Licensed Research Products with a label conveying to end-user purchasers the running-royalty component of a license under the Amplification Patent Rights to use such Licensed Research Products in or with the PCR Process strictly for such purchasers own internal use in the Research Field in conjunction with a thermal cycler whose use is covered by the up-front fee component, either by payment to Licensor or as purchased, and
b)     Licensee may promote Licensed Research Products for such use in or with the PCR Process in the Research Field.  The up-front component of the PCR license for research must be obtained by the end user in order to have a complete license for the automated performance of the PCR Process.  The up-front component may be purchased from Licensor.  Alternatively, it may be obtained through the purchase of thermal cycler(s) or temperature cycling instrument(s) bearing a valid label conveying to purchasers the up-front  component of the license, that is, an Authorized Thermal Cycler.
License Property
The Authorized Thermal Cycler means a thermal cycler or temperature cycling instrument whose use in automated performance of the PCR Process in the Research Field and Application Fields is covered by the up-front fee component of a PCR Process license.  The up-front component of that license may be purchased from Licensor.  Alternatively, the up-front component of that license may be obtained through the purchase of thermal cycler(s)  or temperature cycling instrument(s) bearing a valid label conveying the up-front PCR Process license component.

The Swiss third party Patented Enzymes licensed herein are
a)  native Taq DNA Polymerase, full length, unmutated
b)  recombinant Taq DNA Polymerase, full length, unmutated
c)  Tth DNA Polymerase, full length, unmutated (native or recombinant)

The Licensed Researched Products are any product, including but not limited to kits, which products consist of or contain a Licensed Product and may include all or some of the following components  buffers, nucleotides, enzymes, or other reagents or materials.

Licensed Application Products are Application Kits for a Licensed Application Field or reagents, components or other materials which are sold in connection with the sale of an Applications Kit for a Licensed Application Field by Invitrogen and which are adapted for or promoted or supported for use by customers in PCR Testing or nucleic acid sequencing, or RT AND RT-PCR in Application Fields.

Field of Use
The Application fields include Forensics and Human Identity Applications, Environmental Testing, Agricultural Plant, Animal Identity Testing and Positive Trait Breeding Applications and Food Testing.

IPSCIO Record ID: 209527

License Grant
The Swiss Licensor grants a nonexclusive license in the territory, without the right to sublicense except to its current affiliates as follows
– under TAQ patent rights, to manufacture, but not to have manufactured, to use and to sell, strictly under Licensees or its Affiliates own Trademarks, Tradenames and/or label(s), TAQ Reagents; and
– under Polymerase patent rights, to manufacture, but not to have manufactured, to use and to sell, strictly under Licensees or its Affiliates own Trademarks, Tradenames and/or label(s), Licensor Patented Enzymes other than TAQ Reagents.
License Property
The Licensor Patented Enzymes licensed herein are
a)  native Taq DNA Polymerase, full length, unmutated
b)  recombinant Taq DNA Polymerase, full length, unmutated
c)  Tth DNA Polymerase, full length, unmutated (native or recombinant)

The Licensed Researched Products are any product, including but not limited to kits, which products consist of or contain a Licensed Product and may include all or some of the following components  buffers, nucleotides, enzymes, or other reagents or materials.

Licensed Application Products are Application Kits for a Licensed Application Field or reagents, components or other materials which are sold in connection with the sale of an Applications Kit for a Licensed Application Field by Invitrogen and which are adapted for or promoted or supported for use by customers in PCR Testing or nucleic acid sequencing, or RT AND RT-PCR in Application Fields.

Field of Use
The Application fields include Forensics and Human Identity Applications, Environmental Testing, Agricultural Plant, Animal Identity Testing and Positive Trait Breeding Applications and Food Testing.

IPSCIO Record ID: 146089

License Grant
Licensor grants a nonexclusive immunity from suit under PCR Technology solely to perform Licensed Services.

Licensor grants to Licensee the right to credit the Licensor as the source of PCR Technology in Licensees promotional materials and any other materials intended for distribution.

License Property
PCR or polymerise chain reaction is a nucleic acid amplification process.

Licensed Services means the performance of an IN VITRO diagnostic procedure utilizing PCR Technology to detect the presence, absence or quantity of a nucleic acid sequence associated with a human disease or condition within the Licensed field.

The Diagnostic product shall mean an assemblage of reagents, including but not limited to reagents packaged in the form of a kit, useful in performing a Licensed Service.

The licensed credit is 'This test is performed pursuant to a license agreement with Licensor.'

Field of Use
Licensor has expertise in validating, documenting and performing sophisticated diagnostic procedures.  The field is that of human IN VITRO diagnostics solely for the detection of genetic diseases, genetic predisposition to disease, agents associated with infectious diseases, cancer; and for tissue transplant typing, including testing performed on animal tissue intended for use in xenotransplantation; Parentage determination; disease management; and clinical trials.

IPSCIO Record ID: 202871

License Grant
Pursuant to the original agreement Licensor granted to the Canadian Licensee inter alia, a worldwide exclusive license within the field of use under the patent rights to make, have made, use and sell licensed products.
License Property
The original agreement identifies the licensed product as Licensees chemistry kits that make use of the patent Technology and any chemistry system that makes use of the Technology, not including hardware, software, or non-chemistry components.

Patented technology relates to the coupled amplification and sequencing (CAS) of DNA for diagnostic use.

'PATENT RIGHTS shall include all rights exclusively licensed to Genaissance under U.S. Patent No. 5,427,911

Field of Use
The Field of Use shall mean all diagnostic and research applications, including but not limited to human and veterinary purposes.

The CAS technology is incorporated in Licenso's TruGene-TM- HIV diagnostic kit which is designed to perform pharmacogenomic analysis of HIV and to customize HIV and AIDS therapy for particular patient sub-groups.

IPSCIO Record ID: 243464

License Grant
For the Conditional Non-Exclusive License to Licensee for Instruments, Licensor grants to a nonexclusive, world-wide license under Licensors interest in the Intellectual Property to make, have made, and import, Instruments outside of the Collaboration Field.

For the Non-Exclusive License to Licensee for Instruments Developed Outside the Joint Development Program, Licensor grants a non-exclusive, world-wide license under Licensors interest in Collaboration Licensors Intellectual Property to make, have made, use, import, offer to sell, and sell instruments outside the Collaboration Field.

For the Non-Exclusive License to Licensee for Instruments,  Licensor grants to a non-exclusive world-wide license under Licensors interest in the Intellectual Property to use, offer to sell, and sell Instruments outside of the Collaboration Field.

This agreement also includes exclusive grants from Licensee to Licensor.

License Property
Licensee has certain skills, proprietary technology and know-how related to the manufacture, design and use of Assembled Arrays.

Licensor has certain skills, proprietary technology and know-how related to the development of bioanalytical instrumentation systems and associated reagents and the marketing, sales and support of products incorporating such systems.

Licensor has DNA Synthesis and Purification Patents  referred to as the Caruthers Process and Caruthers Reagents, and related patents.

Field of Use
Collaboration Field means the field of Zip Code Chemistry used in combination with Assembled Arrays.

Nucleic Acid Analysis Field means the field of characterization of a nucleic acid sample including but not limited to the determination of the relative abundance of the nucleic acid, all or part of a sequence of the nucleic acid, or variations in the sequence of the nucleic acid. The Nucleic Acid Analysis Field excludes the Collaboration Field.

The Parties are designing product based on the Array of Arrays for SNP genotyping. The first SNP genotyping assay format that Licensee intend to commercialize will be PE Biosystems' proprietary OLA ZipCode assay format. This assay format enables the creation of a universal Array of Arrays that can be used to analyze any set of SNPs.

IPSCIO Record ID: 289237

License Grant
Licensor hereby grants to Licensee under the Licensed Patents a non-exclusive license, without the right to grant sublicenses, to research and develop, to make, have made (with prior notification to Orchid), sell, offer for sale or otherwise dispose of Licensed Products in the Territory solely for use in the Licensed Field.

Under this license, Licensee may use the Licensed Product only to the extent necessary to perform research and development on Licensed Products for sale hereunder and/or quality control functions on lots of the Licensed Products, but under no circumstances may Licensee use the Licensed Products for Research Purposes or for any other purpose within or outside the Licensed Field.

Licensor additionally grants to Licensee, under the Licensed Patents, a non-exclusive license, without the right to grant sublicenses, to research and develop, to make, have made (with prior notification to Licensor), sell, offer for sale or otherwise dispose of Kits in the Territory to a Third Party Licensee for use in the Licensed Field or otherwise consistent with such Third Party Licensees license from Licensor.

License Property
Licensed Product means a Kit and an End User License.

Kit means a product designed for performing Primer Extension comprising one or more Reagents, the sale or offer for sale of which, without the licenses granted herein, would infringe or contribute to the infringement of at least one claim of a Licensed Patent.

Licensed Patents means US Patent No. 5,888,819 and 6,004,744 and any divisionals, continuations, reissues, and foreign counterparts thereof.  To date foreign patents include the Australian Patent No. 660,173.
5,888,819 – Method for determining nucleotide identity through primer extension
6,004,744 – Method for determining nucleotide identity through extension of immobilized primer

Genotype means the detection or quantification of an individual SNP within a single sample.

'SNP' means single nucleotide polymorphism.

Reagent means an enzyme, buffer, primer extension chain-terminating compound or other composition useful for Primer Extension.

Field of Use
This agreement pertains to methods for determining nucleotide identity.

Average nucleotide identity (ANI) is a comparative measurement between the similarity of two genomes sequences. Here we present a tutorial on R that allows the user to identify and visualize groups of genomic species using the output of different ANI algorithms.

Licensed Field means the use of a Licensed Product on an Approved Instrument for Research Purposes only.

IPSCIO Record ID: 289169

License Grant
Licensor grants to the Swiss Licensee a worldwide, semi-exclusive license, without the right to sublicense, under the Licensor Licensed Patents to research, develop, make, have made, import, use, offer for sale and sell Licensor Licensed Products for use in the Field.

For Licensor Transplantation Field License, Licensor grants a worldwide, non-exclusive license, without the right to sublicense, under Licensor Licensed Patents to research, develop, make, have made, import, use, offer for sale and sell Licensor Licensed Products for use in the Transplantation Field.

For Licensor Future HGV Sequence Patent Rights, Licensor grants to a non-exclusive option to obtain one or more non-exclusive, worldwide licenses, or sublicenses, as the case may be, with a right to sublicense to Licensee Affiliates only, under the Licensor Future HGV Sequence Patent Rights, to make, have made, use, import, offer for sale and sell Licensor Licensed products.

License Property
Licensed Patents means the Licensor Licensed Patents and the Licensee Optioned Patents.

Products  means reagents, compositions or kits suitable for use in the Field or the Transplantation Field.

The patents include NANBV Diagnostics and Vaccines;  Heteroduplex Tracking Assay for Gene Typing; and, Polynucleotide Probes Useful for Screening for HCV.

Both Parties currently own or control certain patent rights relating to the hepatitis C virus (HCV).

Field of Use
The Licensees purpose is for use in assays for the detection of nucleic acid sequences for use in in vitro diagnostics, excluding use in Blood Screening, but without limiting the effect of the Blood Screening Agreement.

Field means the commercial use of human in vitro diagnostic products that detect nucleic acid sequences of HCV. Expressly excluded from the Field are products in Blood Screening; products specifically labeled or promoted for use in the Transplantation Field.

Transplantation Field means the commercial use of products that detect nucleic acid sequences for the screening of any biological materials intended for transfusion or transplantation, in each case from any donor, including autologous donors, other than the transfusion or transplantation of blood or its derivatives, components or replacements.

IPSCIO Record ID: 291157

License Grant
Licensor shall (A) grant to Licensee a non-exclusive, non-transferable, royalty-free license to exploit such TAG Improvement for Licensees internal use, and (B) shall include internal use rights to use such TAG Improvement within the licenses granted to Product customers.

The purpose of the Collaboration is to develop, manufacture, market and sell (i) Products, and (ii) software applications for Approved Instruments all as set forth in this agreement. The purpose of the Collaboration may be modified and/or extended upon mutual agreement of the Parties in writing. If Licensee is the Party proposing the development of a new Generic Kit or Standard Kit, and Licensor does not, within sixty (60) days after receipt of such New Kit Notice expressly agree to co-develop the new Generic Kit or Standard Kit described therein, then Licensee may pursue development of the new Generic Kit or Standard Kit independently of Licensor and the result is a combination kit then a royalty will be paid.

License Property
TAG Array means a tag array GeneChip probe array. Each set of probes consists of four probes with the following relationship to a defined target sequence — a perfect match to target sequence, a single base mismatch to target sequence, a perfect match to the complement of target sequence, and, a single base mismatch to the complement of target sequence. For the avoidance of doubt, TAG Arrays include no license (express or implied) authorizing use for any purpose except genotyping with GBA.

TAG Assay means any assays for hybridization to a TAG Array.

TAG improvement is any improvements to TAG Assays.

Product means any of a Standard Kit, a Custom Kit and/or a Generic Kit.

Combination Kit means any Custom Kit that contains Primers more than 50% of which are identical to Primers contained in any part of any Standard Kits existing at the time of launch of such Custom Kit, or any combination of Standard Kits existing at the time of launch of such Custom Kit.

Custom Kit means a kit consisting of certain Reagents, certain Primers that have been customized by Licensee or Licensees subcontractors for use in the Field of Use and an End User License, and shall not include use of or refer to any use of TAG Arrays other than for genotyping with GBA.

Standard Kit means a kit consisting of Reagents, CMC Approved Primers for use in the Field of Use and an End User License.

Generic Kit means a kit consisting of Reagents and an End User License.

Primer means GBA primers (a synthetic oligonucleotide of a sequence known to be complementary with the oligonucleotide sequence immediately adjacent, 5, to a SNP) or either PCR primers or information to generate PCR primers.

Reagent means buffers, enzymes and terminators (but not Primers) useful in GBA.

GBA means Genetic Bit Analysis, or single nucleotide primer extension methods designed to detect the identity of a single nucleotide at a predetermined location in the DNA of a sample.

SNP means Single Nucleotide Polymorphism.

Technology means and includes all inventions, discoveries, improvements, trade secrets and proprietary methods and materials, whether or not patentable, including but not limited to, samples of, methods of production or use of, and structural and functional information pertaining to, chemical compounds, proteins or other biological substances; other data; formulations; techniques; and know-how; including any negative results.

TAG Array means a tag array GeneChip probe array. Each set of probes consists of four probes with the following relationship to a defined target sequence — a perfect match to target sequence, a single base mismatch to target sequence, a perfect match to the complement of target sequence, and, a single base mismatch to the complement of target sequence. For the avoidance of doubt, TAG Arrays include no license (express or implied) authorizing use for any purpose except genotyping with GBA.

TAG Assay means any assays for hybridization to a TAG Array.

Field of Use
The first products to be commercialized by the alliance will include reagent kits for use with Licensor's new universal array designed to perform thousands of user-defined SNP analyses. The companies expect to follow this product launch with additional genotyping products that incorporate additional universal arrays and GBA reagents. Licensee will develop and manufacture GBA primer extension reagent kits that are directed to defined sets of SNPs and that can be customized by the end user. Licensor will develop and manufacture the universal GeneChip arrays.

Field of Use means the use of Product to practice GBA in Tag Array format in Approved Instruments for Research Purposes and clinical reference laboratories where work is performed under the Clinical Laboratory Improvements Act and explicitly excludes Products that have received marketing approval from the FDA.

IPSCIO Record ID: 299242

License Grant
English Licensor hereby grants to Licensee and Licensee accepts, a non-exclusive, royalty-bearing, worldwide sub-license under the Licensor Patent Rights to manufacture, have manufactured and use Nucleic Acid Arrays for internal purposes only, to create and contribute to the creation of Licensee Ratio-based Databases, and to Supply and offer for Supply Royalty-Bearing Services, in each case in all fields other than the Excluded Fields.
License Property
Nucleic Acid Array means an array of nucleic acids attached to a solid support.

Licensee Ratio-Based Database means a Database containing relative levels of expressed genes within or between cells wherein such Database may be built from data where measurements from one RNA sample are compared with those from another RNA sample; provided, however, a Licensee Ratio-based Database shall in no event include an Incyte Expression Database.

Resolver Software means Licensees software package with features.

Instrument means readers, fluids stations, hybridization devices, sample logging, handling and processing systems, detection and measurement equipment, computer work stations (and associated software) and other instruments or systems used in the preparation or use of Nucleic Acid Arrays or the extraction or processing of data from Nucleic Acid Arrays.

Patent Rights means U.S Patents #5,700,637 and 5,436,327 and International Application No. PCT/GB/89/00460 and PCT/GB/89/01114 and all continuations, continuations-in-part, divisionals, re-examinations and reissues, and any patents issuing therefrom or claiming common priority thereto, together with any other patents which issue to Licensor, or which otherwise come into the ownership or under the control of Licensor during the Term and which Licensor has the right to license, and which relate, but only to the extent that they relate, to the general use of Nucleic Acid Arrays, including methods for making or analyzing Nucleic Acid Arrays and for creating Licensee Ratio-based Databases, but excluding therefrom any such patents that relate but only to the extent that they relate to instrumentation for the reading of Nucleic Acid Arrays, the design of probes for use on Nucleic Acid Arrays, particular sequences used on Nucleic Acid Arrays, software used in instrumentation for reading Nucleic Acid Arrays or in probe design, microfluidics or the control or assurance of the quality of Nucleic Acid Arrays.
5,700,637 – Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
5,436,327 – Support-bound oligonucleotides

Licensed Product means a Nucleic Acid Array and any component thereof, an Instrument, kit, reagent, computer software or other product, apparatus or composition of matter of whatever nature which is Covered by a Valid Claim, but not including a Database or other information (other than a Database or information which is an integral part of a product).

In-Situ Inkjet Synthesis means a method for the fabrication of Nucleic Acid Arrays on a solid support by synthesizing by chemical means individual nucleic acids directly on such solid support at specific locations on the Nucleic Acid Array using an inkjet printing device to deliver to defined locations on the surface of the solid support precursors for or reagents which allow mononucleotide additions.

Incyte Expression Database means a Database consisting entirely or substantially of gene expression data and containing at least five hundred data points, where a single data point is data relating to the level of expression of one gene in one sample.

Database means a collection of information derived from one or more Nucleic Acid Arrays, which is licensed for value to multiple third parties, but does not include a database for internal use exclusively by an Entity.

Field of Use
This agreement pertain to the drug industry in all fields other than the Excluded Fields.

Excluded Fields means any of the following activities
            (a)   the use of a Nucleic Acid Array for or in connection with any activity other than gene expression profiling or non-commercial genotyping;
            (b)   the exercise of any of the rights licensed under this Agreement for the purposes of the manufacture, having manufactured, use, Supply, creation or contribution to the creation of Incyte Expression Databases; and
            (c)  [the manufacture or having manufactured of Nucleic Acid Arrays by a method other than In-Situ Inkjet Synthesis.

Licensee is  a leader in the emerging field of informational genomics. Informational genomics involves acquiring, storing, and analyzing gene expression information gathered from throughout a cell to identify a majority of the medically important drug targets and gene functions. Licensee combines the power of informatics and genomics to create a proprietary platform that accelerates and enhances the drug discovery process for pharmaceutical and biotechnology companies and improves agricultural products.

IPSCIO Record ID: 291108

License Grant
German Licensor hereby grants and Licensee hereby accepts a semi-exclusive license, subject only to the Existing License, under Licensed Patents to manufacture, have manufactured, market, use, import, and sell Licensed Products in the Territory. Licensee shall have a right to sublicense under the terms set forth and as long as Licensee fulfills the conditions for a semi-exclusive license.

Except for the Existing License Licensor will not grant any additional license in the Field for at least 3 years from the effective date. Beginning on the fourth anniversary of the effective date of this Agreement, Licensor will not grant any additional license in the Field as long as Licensee pays the semi-exclusive minimal license fee set forth.

Licensor agrees that during the time Licensee is semi-exclusively licensed hereunder, Licensor will cause the Existing Licensee to agree to accept a non-exclusive license excluding the Field should the Existing Licensee be acquired by another party or should the Existing Licensee sell the technology for which it requires a license under the Licensed Patents.

License Property
Licensed Patents shall mean the patent applications and patents listed as well as any addition, continuation, continuation-in-part, division, extension, reissue, re-examination, application or substitution with respect thereto.

6,087,095 – DNA sequencing method

Licensed Products shall mean an instrument, associated consumables and/or kit/s exclusively designed for analyzing a target polynucleotide sequence on a support, that would, in the absence of this deblocking License, infringe Licensed Patents.

Field of Use
Field shall mean the analysis of a target polynucleotide sequence on a support.

IPSCIO Record ID: 291130

License Grant
Licensor hereby grants to Licensee, and Licensee hereby accepts from Licensor, a royalty-bearing, non exclusive, personal, non-transferable license under the Licensed Technology solely to perform Licensed Services within the Territory.

Licensor hereby grants to Licensee the right and Licensee accepts and agrees to credit Licensor as the source of its Licensed Technology rights in Licensees promotional materials and any other materials intended for distribution to Third Parties as follows

License Property
Licensor owns and has the right to grant licenses to practice under certain United States Patents describing and claiming, inter alia, nucleic acid amplification processes known as polymerase chain reaction ('PCR'), homogeneous PCR, and RT-PCR ('reverse transcription PCR').

Licensed Technology shall mean, subject to the following limitations, the Valid Claims of the United States patents listed in Agreement and any reissue or reexamination patents thereof. No rights under any kit claims of such patents are included in this definition or licensed under this Agreement. With the exception of the reaction mixture claims of United States Patents Nos. 5,804,375, 5,693,517, 5,476,774 and 6,127,155, the plasmid claims of the 5,476,774 patent, the primer claims of United States Patent No. 5,573,906, and the probe claims of United States Patent No. 5,110,920, no rights under any apparatus, device, composition of matter, reagent or substance claims of such patents are included in this definition or licensed under this Agreement.
4,683,195 – Process for amplifying, detecting, and/or-cloning nucleic acid sequences
4,683,202 – Process for amplifying nucleic acid sequences
4,965,188 – Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme

Diagnostic Product shall mean an assemblage of reagents, including but not limited to reagents packaged in the form of a kit, useful in performing a Licensed Service.

Licensed Service(s) shall mean the performance by Licensee of an in vitro procedure within the Licensed Field which utilizes the Licensed Technology. Licensed Services include, but are not limited to, any combination of the steps of collecting a sample for analysis, isolating nucleic acid sequences from the sample, amplifying one or more desired sequences, analyzing the amplified material, including sequence analysis, and reporting the results.

Field of Use
Licensed technology includes specified nucleic acid amplification processes, to perform certain polymerase chain reaction-based human in vitro clinical laboratory services.

Licensed Field shall mean the field of clinical laboratory services that detect the presence, absence and/or quantity of a nucleic acid sequence for the detection, diagnosis, confirmation, prognosis, management and/or treatment of a human disease or condition, including, but not limited to, such services to identify predisposition to disease, disease susceptibility, confirm disease, predict therapeutic effectiveness or monitor disease progress; used in the course of human clinical trials; for Parentage Determination; and for tissue transplant typing, including testing performed on animal tissue intended for use in xenotransplantation. Licensed Field shall specifically exclude any services performed for the screening of blood and/or blood products.

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