Royalty Report: Diagnostic, Cancer, Drugs – Collection: 223142

License Grant

Licensor hereby grants to Licensee a royalty-bearing, exclusive right and license, with the right to sublicense as provided in this agreement, under the Licensed Patents and Know-How, to conduct research and to develop, make and have made, sell, offer to sell and have sold, import and have imported Licensed Products in the Field in the Territory; provided, however, that such license grant is subject to the restrictions set forth.

License Property

Licensed Patents
6,284,241 – Compounds for immunotherapy and diagnosis of colon cancer and methods for their use
6,312,695 – Compounds and methods for therapy of lung cancer
6,660,838 – Compounds and methods for therapy and diagnosis of lung cancer

Field of Use

Field shall mean the field of in vitro nucleic acid-based and antibody-based cancer diagnostics.

License Grant

The German Licensor hereby grants to Licensee an exclusive license (including the right to grant sublicenses) under the Licensed Patent Rights to conduct research and to develop, make, use, offer for sale, sell and import Licensed Products and to provide Services in the Territory.

License Property

Licensed Patent Rights shall mean (a) those certain patent applications and patents listed hereto; (b) all patents that have issued or in the future issue from such foregoing patent applications, including utility, model and design patents and certificates of invention; (c) all patents that have issued or in the future issue from any patent application that claims priority from, or common priority with, any of the foregoing patent applications, including utility, model and design patents and certificates of invention; and (d) all divisionals, continuations, continuations-in-part, reissues, renewals, extensions or additions to any such foregoing patent
applications and patents.

W003023057 (PCT /EP02/05489) – Method and Diagnosis Kit for Selection and/or for Qualitative and/or Quantitative Detection of Cells

Licensed Products shall mean in-vitro diagnostic assays to isolate, detect, identify, quantify, or test for drug susceptibility of, one or more proteins or nucleic acid sequences as diagnostic indicators for the presence of prostate cancer and/or bladder cancer, for the purpose of research, diagnosis or medical care, the  manufacture, use, sale offer for sale or importation of which would, but for the license herein granted by AdnaGen to Gen-Probe, infringe one or more Valid Claims of the AdnaGen Patent Rights.

Field of Use

This agreement pertains to the medical industry relating to certain technology concerning the qualitative and quantitative detection of cells which may be useful in connection with nucleic acid diagnostic assays. The diagnostic indicators are used for the presence of prostate cancer and/or bladder cancer, for the purpose of research, diagnosis or medical care.

'Group 1 Additional Products' shall mean in-vitro diagnostic assays to isolate, detect, identify or quantify, or test for drug susceptibility of, one or more proteins or nucleic acid sequences as diagnostic indicators for the presence of kidney cancer, cervical cancer, and/or ovarian cancer, for the purpose of research, diagnosis or medical care, the manufacture, use, sale offer for sale or importation of which would, but for the license herein granted by AdnaGen to Gen-Probe, infringe one or more Valid Claims of the Licensed Patent Rights.

'Group 2 Additional Products' shall mean in-vitro diagnostic assays to isolate, detect, identify or quantify, or test for drug susceptibility of, one or more proteins or nucleic acid sequences as diagnostic indicators for the presence of lung cancer, colon cancer, and/or breast cancer, for the purpose of research, diagnosis or medical care, the manufacture, use, sale offer for sale or importation of which would, but for the license herein granted by AdnaGen to Gen-Probe, infringe one or more Valid Claims of the Licensed Patent Rights.

License Grant

The Licensor grants grants the Licensee an exclusive, royalty-bearing, non-transferable , sublicensable license under the Licensed Patents and Technical Information,  relating to molecular diagnostics for lung cancer, solely to make, have made, use, sell, offer for sale, and import the Licensed Products in the Licensed Field in the Territory during the Term.

License Property

62/163,766 Methods and Compositions for Diagnosing or Detecting Lung Cancers – Patent rights and technical information and know-how relating to molecular diagnostics for lung cancer, including, but not limited to confirmatory, companion and recurrence diagnostics for any type of lung cancer with detection through whole blood, fractionated blood, plasma, serum and/or other biological samples.

Field of Use

The Licensee  will obtain a license under such patent rights, technical information and know-how to develop and commercialize products for the non invasive cancer diagnostic testing including for lung cancer.

License Grant

Licensor, a not-for-profit corporation formed to manage intellectual property developed at a university, grants an exclusive license under Patent Rights to manufacture, have manufactured, distribute, have distributed, use, offer for Sale, Sell, lease, loan and/or import Licensed Products in the Field of Use in the Territory and to perform Licensed Services in the Field of Use in the Territory.

Licensor grants a non- exclusive sublicense under Technology Rights to manufacture, have manufactured, distribute, have distributed, use, offer for Sale, Sell, lease, loan and/or import Licensed Products in the Field of Use in the Territory and to perform Licensed Services in the Field of Use in the Territory.

License Property

Licensor owns, controls and/or has the right to sublicense the Licensed Subject Matter which is the licensed patents and technology.

The patents include
MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Solid Cancers
Compositions and Methods for the Diagnosis and Therapy of BCL2-Associated Cancers
MicroRNA Based Methods and Compositions for the Diagnosis and Treatment of Colon Related Diseases
Ultraconserved Regions Encoding ncRNAs
Methods for Identifying Fragile Histidine Triad (Fhit) Interaction and Uses Thereof
Materials and Methods Related to Modulation of Mismatch Repair and Genomic Stability by miR-155
Materials and Methods Related to MicroRNA-21. Mismatch Repair, And Colorectal Cancer
Mutator activity induced by microRNA-155 (miR-155) Links Inflammation and Cancer
Methods and Compositions Related to miR-21 & miR-29a and Cancer Metastasis
Mechanism of NSAID Chemoprevention in Colorectal Cancer

Licensed Product means any product, apparatus, kit, test having a panel of either a single nucleotide or two or more nucleotides in combination or component thereof whose manufacture, use, sale, offer for sale or import is Covered By any claim or claims included within the Patent Rights or incorporates any Technology Rights, or which is made using a Licensed Process or another Licensed Product.

Field of Use

Exclusive Field of Use is for the diagnosis, prognosis and therapy/treatment of colon cancer.

License Grant

Licensor of Germany grants to the Licensee of Belgium an exclusive worldwide license, with the right to grant sublicenses, under the Licensed IP and Licensor Technology in the Field to develop, have developed, make, have made, use, have used, sell, have sold, import, to have imported, offer for sale and have offered for sale Licensed Products in the Territory.

Licensor grants a non-exclusive worldwide license, with the right to grant sublicenses, under the Licensed IP and Licensor Technology in the Field to develop, have developed, make, have made, use, have used, sell, have sold, import, co have imported, offer for sale and have offered for sale Licensed Products in the Territory. This will secure Licensees non-exclusive access to Licensors Collect technology.

Licensor grants the right to extend the right to use such Licensed Product to their customers of the Licensed Product on which the royalty is paid, label license.

License Property

Licensor owns or controls, on a worldwide basis, the rights, titles and interests in certain patent rights, relating to circulating tumor cells technology.

Licensed Products encompass the components Collect, Select and Detect.

NAT is nucleic acid amplification technology.

Platforms shall mean technologies employed in Licensed Products as well as competitive products based on the same or essentially similar technologies (employing the same scientific or technical principles), used in LIPA, 4•MAT and Luminex systems or certain, identified Real Time PCR technology.

Patents include
Colon cancer Method and Kit for the diagnosis of therapy of colon cancer
Breast cancer Method and Kit for the diagnosis of therapy of breast cancer
Core patent Method and diagnosis kit for selection and/or quantitative detection of cells
Reagency and method for preventing time-dependent RNA -expression in biological cells

Field of Use

The field shall mean circulating tumor cell isolation and detection using existing and future Licensor Technology for breast, colon, lung and upon availability, prostate cancer.

License Grant

Licensor, an individual, hereby grants to Licensee an exclusive, royalty-bearing license, including the right to grant sublicenses to the Licensed Patent Rights and Licensed Technology and Licensor's interest in any Improvements, to Develop, have Developed, make, have made, use, have used, sell, offer for sale, have sold, import, have imported, export and have exported, Licensed Products and to practice the Licensed Technology.

License Property

US 6,004,528  9/18/97/12/21/99
Methods of cancer diagnosis and therapy targeted against the cancer stemline

USSN  09/468,286  12/20/99    
Methods of cancer diagnosis and therapy targeted against the cancer stemline

USSN   60/300,389  6/22/01
Novel Method of Regenerative and Cancer Therapy  

USSN   10/177,886  6/21/02
Methods of Manipulation of the Fate of Cells

Field of Use

The Licensed Field means all uses in all fields relating to the prevention, diagnosis or treatment of cancer in humans.