Royalty Report: Medical, Device, Surgical – Collection: 203456

$150.00

Curated Royalty Rate Report
Category: Technology Licenses, Created On: 2022-04-28, Record Count: 20

Description

This collection of transactions and supporting information was developed using our AI algorithm to curate similar royalty reports into a cohesive collection to support your licensing, transfer pricing or other transaction scenarios where documented royalty rates and/or deal terms are important.
Category: Technology Licenses
Created On: 2022-04-28
Record Count: 20

Primary Industries

  • Medical
  • Device
  • Surgical
  • Coating
  • Catheter
  • Radiation
  • Therapeutic
  • X-ray
  • Chemicals
  • Delivery
  • Diagnostic
  • cardiac
  • Cancer

IPSCIO Report Record List

Below you will find the records curated into this collection.  This summary includes the complete licensed property description so that you can review and determine if this collection covers the topics, technology or transaction type that is relevant for your needs.  The full report will include all relevant deal data such as the royalty base, agreement date, term description, royalty rates and other deal terms.  For reference, here is a sample of a full IPSCIO curated royalty rate report: Sample Report

IPSCIO Record ID: 203456

License Grant
Attached to this settlement agreement, the Licensor grants a worldwide non-exclusive license under Licensors Patent Rights and Know-how to make, have made for it, use, and sell Licensed Products. The license granted herein is expressly limited to the specific Licensed Products defined herein, and does not include the right to sublicense except to an Affiliate.

This license granted for Laser Angioplasty Catheters is non-cancelable by Licensee during the period from the Effective Date through June 30, 2009.

This license granted for Non-Laser Functioning Catheters and Guidewires for use with Licensees Laser Therapy Systems is non-exclusive.

License Property
The licensors patents include, but are not limited to, Method of Improving the Biocompatibility of Solid Surfaces, Surface Coating Agents and Substrate Surface Preparation.

The Licensed Products means Medical Products that are surface-treated with photoreactive polyvinylpyrrolidone copolymer, non-photoreactive polyvinylpyrrolidone, photoreactive polyacrylamide copolymer, one or more of the photoreactive crosslinking agents known to the parties as PR01 and PR04, a compound for promoting polymer-to-metal adhesion known to the parties as TL03, or any combination of these compounds, for the purpose of providing a lubricious surface to the Medical Products.

MEDICAL PRODUCTS-B1 Laser Angioplasty Catheters
The Medical Products means excimer laser angioplasty catheters specifically adapted for coronary and peripheral use. Medical Products includes Licensees chronic total occlusion laser angioplasty catheters.

MEDICAL PRODUCTS-B2 Non-Laser Functioning Catheters and Guidewires for use with Spectranetics Laser Therapy Systems
The Medical Products means the following Licensee-labeled non-laser functioning catheters and guidewires for Licensees laser therapy system that are specifically designed and labeled for use solely with laser angioplasty catheters (I) BIAS sheath, (ii) support catheters, (iii) cardiac lead locking device, and (iv) chronic total occlusion steerwires.  Medical Products does not include catheters for (I) infusion of diagnostic, therapeutic, or embolic agents in the neurovascular region, or (ii) insertion of therapeutic embolic devices in the neurovascular region. Medical Products does not include catheters used to deliver stents of any type.

Field of Use
Licensee designs, manufactures, markets and distributes single-use medical devices used in minimally invasive surgical procedures within the vascular system in conjunction with our proprietary excimer laser system.

IPSCIO Record ID: 27987

License Grant
The Company grants to Licensee, a separate worldwide license under the Licensor's Patent Rights and Know-how to make, have made for it by a Manufacturer as defined herein, use and sell that Licensed Product.

The license granted under this Attachment is non-exclusive.

License Property
The Company is engaged in biological, chemical and technical research and has developed a body of technology and know-how, including reagents, processes and devices which the parties believe will improve the performance of various products and processes

“Licensed Products” means Medical Products which are surface-treated with photo-reactive polyvinylpyrrolidone, photo-reactive heparin, diphoto diquat (photo-reactive crosslinking compound) or any combination of these photo-reactive reagents.

“Medical Products” means a single-use, temporary (less than 7 days) catheter placed within the vascular system that is designed, labeled and approved (as may be required by appropriate governmental authority prior to sale) for the purpose of in situ heating or cooling of blood. For the avoidance of doubt, such catheters shall not be designed, labeled or approved for the purpose of infusing or delivering any therapeutic or embolic agents or for the delivery or placement of permanently implantable therapeutic devices (including embolic devices), while the distal tip of such catheter resides at or above the common carotid artery. For purposes of this Attachment B1, saline solutions and contrast media (for placement or diagnostic purposes) are not considered therapeutic agents.

U.S. Patents
1.
METHOD OF IMPROVING THE BIOCOMPATIBILITY OF SOLID SURFACES

U.S.
Patent No. 4,973,493 issued 11/27/90

2.
BIOCOMPATIBLE COATINGS FOR SOLID SURFACES

U.S.
Patent No. 4,979,959 issued 12/25/90

3.
PREPARATION OF POLYMERIC SURFACES VIA COVALENTLY ATTACHING POLYMERS

U.S.
Patent No. 5,002,582 issued 3/26/91

4.
BIOMOLECULE ATTACHMENT TO HYDROPHOBIC SURFACES

U.S.
Patent No. 5,217,492 issued 6/8/93

5.
METHOD OF BIOMOLECULE ATTACHMENT TO HYDROPHOBIC SURFACES

U.S.
Patent No. 5,258,041 issued 11/2/93

6.
BIOCOMPATIBLE DEVICE WITH COVALENTLY BONDED BIOCOMPATIBLE AGENT

U.S.
Patent No. 5,263,992 issued 11/23/93

7.
RESTRAINED MULTIFUNCTIONAL REAGENT FOR SURFACE MODIFICATION

U.S.
Patent No. 5,414,075 issued 5/9/95

8.
SUBSTRATE SURFACE PREPARATION

U.S.
Patent No. 5,512,329 issued 4/30/96

9.
PREPARATION OF CROSSLINKED MATRICES CONTAINING COVALENTLY IMMOBILIZED CHEMICAL SPECIES AND UNBOUND RELEASABLE CHEMICAL SPECIES

U.S.
Patent No. 5,563,056 issued 10/08/96

10.
RESTRAINED MULTIFUNCTIONAL REAGENT FOR SURFACE MODIFICATION

U.S.
Patent No. 5,637,460 issued 6/10/97

11.
PHOTOACTIVATABLE WATER SOLUBLE CROSSLINKING AGENTS CONTAINING AN ONIUM GROUP

U.S.
Patent No. 5,714,360 issued 02/03/98

U.S. Patent Applications
1.
VIRUS INACTIVATING COATINGS

Filed 6/7/95
2.
METHOD AND IMPLANTABLE ARTICLE FOR PROMOTING ENDOTHELIALIZATION

Filed 5/26/95

Foreign Patents
1.
IMPROVEMENT OF THE BIOCOMPATIBILITY OF SOLID SURFACES

Canadian Patent No. 1305068, issued 7/14/92
Australian Patent No. 615637, issued 10/16/87
EPO Patent No. 0326579, issued 1/11/95
2.
BIOMOLECULE ATTACHED TO A SOLID SURFACE BY MEANS OF A SPACER AND METHODS OF ATTACHING BIOMOLECULES TO SURFACES

Canadian Patent No. 1335721, issued 5/30/95

Foreign Patent Applications
1.
BIOCOMPATIBLE COATINGS

Filed in Canada, Europe, Japan, Denmark, and Norway
2.
PREPARATION OF POLYMERIC SURFACES

Filed in Canada, Europe, Japan, Denmark, and Norway
3.
IMMOBILIZATION OF CHEMICAL SPECIES IN CROSSLINKED MATRICES

Filed in Canada, Europe, Australia, Japan
4.
IMPROVEMENT OF THE BIOCOMPATIBILITY OF SOLID SURFACES

Filed in Japan
5.
RESTRAINED MULTIFUNCTIONAL REAGENTS FOR SURFACE MODIFICATION

Filed in Canada, Europe, Australia and Japan

IPSCIO Record ID: 222533

License Grant
Licensor grants to Licensee, a separate worldwide license under Licensor’s Patent Rights and Know-how to make, have made for it only by a properly sublicensed Manufacturer as set forth herein, use, import, and sell that Licensed Product. The license granted herein is expressly limited to the specific Licensed Products defined herein, and does not include the right to sublicense except as set forth.  All licenses granted by Licensor to Licensee under this Agreement are non-exclusive unless specifically stated otherwise for a particular Licensed Product.
License Property
Licensed Products means each of the separately sold Medical Products that bear a Hemocompatable Coating and a Drug Delivery Coating.

Medical Products means the vessel connector and flow-limiter components of a surgically implanted graft prosthetic system for coupling vascular members in the coronary asculature, such as the vessel connector and flow-limiter components of the devices in the illustrations in U.S. Patent 6,241,764 B1.

6,241,764 – Stented grafts for coupling vascular members

Drug-Delivery Coating means chemical compositions comprised of poly(ethylene-co-vinyl acetate) and poly(butyl methacrylate) components for the purpose of releasing Compounds from the chemical composition.

Hemocompatable Coating means chemical coating compositions that contain one or more of the following components photo-reactive polyvinylpyrrolidone copolymer, nonphoto-reactive polyvinylpyrrolidone, photo-reactive heparin, a crosslinking agent known to the parties as PR04, and a compound for promoting polymer-to-metal adhesion and known to the parties as TL03, for the purpose of providing a hemocompatable surface to the Medical Products.

Licensor U.S. Patents

Hemocompatable Coating formulations

1.

METHOD OF IMPROVING THE BIOCOMPATIBILITY OF SOLID SURFACES
U.S. Patent No. 4,973,493 issued 11/27/1990

2.

BIOCOMPATIBLE COATINGS FOR SOLID SURFACES
U.S. Patent No. 4,979,959 issued 12/25/1990

3.

PREPARATION OF POLYMERIC SURFACES VIA COVALENTLY ATTACHING POLYMERS
U.S. Patent No. 5,002,582 issued 3/26/1991

4.

BIOCOMPATIBLE DEVICE WITH COVALENTLY BONDED BIOCOMPATIBLE AGENT
U.S. Patent No. 5,263,992 issued 11/23/1993

5.

SUBSTRATE SURFACE PREPARATION
U.S. Patent No. 5,512,329 issued 4/30/1996

6.

PHOTOACTIVATABLE CROSS-LINKING AGENTS CONTAINING CHARGED GROUPS FOR WATER SOLUBILITY
U.S. Patent No. 6,077,698 issued 06/20/2000

7.

SURFACE COATING AGENTS
U.S. Patent No. 6,278,018 B1 issued 08/21/2001

8.

SURFACE COATING AGENT
U.S. Patent No. 6,603,040B1 issued 8/05/2003

9.

SILANE COATING COMPOSITION
U.S. Patent No. 6,706,408B2 issued 3/16/2004
Drug-Delivery Coating formulations

1.

BIOACTIVE AGENT RELEASE COATING
U.S. Patent No. 6,214,901B1 issued 04/10/2001

2.

BIOACTIVE AGENT RELEASE COATING
U.S. Patent No. 6,344,035B1 issued 02/05/2002

Field of Use
This agreement pertains to coating on medical related devices such as stent.

IPSCIO Record ID: 27092

License Grant
The Company hereby grants to Licensee and its Affiliates, upon the terms and subject to the conditions set forth herein, a worldwide, exclusive right and sublicense under USC Patent Rights in the Field of Use.
License Property
Guardian Embolization Protection System patented technology for primary use in the neurointerventional and cardiology markets these markets focus on arteries and veins leading to the brain and those in the heart, and the removal of blockages in these veins and arteries.  The device is designed to prevent deadly embolisms during surgery to clear blocked arteries and prevent strokes and heart attacks.  The key to this device, known as the Guardian System, is a thin string of wire, really a metal tube not much larger in diameter than a human hair, with a marble-sized balloon attached toward the end.
Field of Use
'Field of Use' shall mean diagnostic and/or therapeutic devices used in the treatment or management of patients via the carotid artery or other arteries or veins.

IPSCIO Record ID: 372575

License Grant
Licensor grants a separate worldwide license under Licensors Patent Rights and Know-how to make, have made for it, use, import, have imported, offer for sale and sell that Licensed Product.  The license granted for Atherectomy Catheter is non-exclusive.
License Property
Licensor is engaged in biological, chemical and technical research and has developed a body of technology and know-how including reagents, processes and devices.

The patents are Latent Reactive Chemical Patents.

The Licensed Products means each of the separately sold Medical Products.

Medical Products means a catheter that is specifically designed and labeled to excise stenotic, sclerotic materials from the coronary vascular and peripheral vascular systems.

Licensed Products means Medical Products which are surface-treated with photo-reactive polyacrylamide, photo-reactive polyvinylpyrrolidone, tetrabenzoylbenzyl ether or diphotodiquat, latent-reactive crosslinking compounds, or any combination of these photo-reactive reagents.

U.S. Patents
1. METHOD OF IMPROVING THE BIOCOMPATIBILITY OF SOLID SURFACES
U.S. Patent No. 4,973,493

2. BIOCOMPATIBLE COATINGS FOR SOLID SURFACES

U.S. Patent No. 4,979,959
3. PREPARATION OF POLYMERIC SURFACES VIA COVALENTLY ATTACHING POLYMERS
U.S. Patent No. 5,002,582

4. BIOMOLECULE ATTACHMENT TO HYDROPHOBIC SURFACES
U.S. Patent No. 5,217,492

5. METHOD OF BIOMOLECULE ATTACHMENT TO HYDROPHOBIC SURFACES
U.S. Patent No. 5,258,041

6. BIOCOMPATIBLE DEVICE WITH COVALENTLY BONDED BIOCOMPATIBLE AGENT
U.S. Patent No. 5,263,992

7. RESTRAINED MULTIFUNCTIONAL REAGENT FOR SURFACE MODIFICATION
U.S. Patent No. 5,414,075

8. SUBSTRATE SURFACE PREPARATION
U.S. Patent No. 5,512,329

9. PREPARATION OF CROSSLINKED MATRICES CONTAINING COVALENTLY IMMOBILIZED CHEMICAL SPECIES AND UNBOUND RELEASABLE CHEMICAL SPECIES
U.S. Patent No. 5,563,056

10. RESTRAINED MULTIFUNCTIONAL REAGENT FOR SURFACE MODIFICATION
U.S. Patent No. 5,637,460

11. PHOTOACTIV A TABLE WATER SOLUBLE CROSSLINKING AGENTS CONTAINING AN ONIUM GROUP
U.S. Patent No. 5,714,360

Field of Use
The master license agreement is for the right to coat catheters with certain proprietary coating materials.

IPSCIO Record ID: 714

License Grant
Licensor, an individual, hereby grants to Licensee a world-wide exclusive, nontransferable, personal, sublicenseable only to those companies against which Licensee enforces the Rentrop Patents pursuant to this Agreement, revocable, royalty-bearing license under the Rentrop Patents to make, use, offer for sale, import, sell, or otherwise dispose of Licensed Catheters.
Licensor hereby grants to the Licensee a world-wide exclusive, nontransferable, personal, subLicenseable, as a result of the litigation in the U.S. District Court for the Southern District of New York. The Litigation was tried to the jury, resulting in a jury verdict on December 8, 2006 of infringement of claims 1, 8, and 15-17 of U.S. Patent Nos. 6,673,064. The License granted under this Agreement shall continue in full force and effect from the effective date until January 4, 2020.
License Property
Licensor is the sole inventor of and owns all right, title, and interest in and to U.S. Patent Nos. 6,440,125 and 6,673,064 and any applications claiming priority thereto.

IPSCIO Record ID: 118680

License Grant
Licensor granted us a non-exclusive license to its patent covering excimer laser ablation of tissue.  The terms of the license permit us to sublicense our subsidiaries.
License Property
The excimer laser systems and related products are used to perform procedures that correct common refractive vision disorders such as nearsightedness, farsightedness and astigmatism.
Field of Use
Laser vision correction is a surgical procedure for correcting disorders such as nearsightedness, farsightedness and astigmatism using an excimer laser. This procedure uses ultraviolet laser energy to remove tissue from the surface of, and thus sculpt, the cornea into a predetermined shape. Because the excimer laser is a cold laser, it is possible to ablate, or remove precise amounts of corneal tissue without causing thermal damage to surrounding tissue. The goal of laser vision correction is to eliminate or reduce a persons reliance on corrective eyewear.

IPSCIO Record ID: 372411

License Grant
This license is granted upon execution of the option to license and already accepted by Licensee. With Licensee exercising the option to license, Licensee is additionally granted  a non-exclusive, sublicensable license in the field for the countries Licensor is not able to fulfill Sections 3.8 or 3.9 to use any Background Patents necessary for the use and exploitation of the Catheter Technology, Peripheral Technology or Product to the extent related to the Application.
License Property
Licensor is a leading company developing, manufacturing and selling devices as well as developing treatment plans for various medical indications, such as deep brain stimulation or cardiac ablation.

Product shall mean and comprise a combination of hardware, software and workflow procedures allowing the performance of the Application or parts thereof under simultaneous MR imaging, which the Parties wish to develop under this Agreement and which is defined in more detail in Agreement. The Product shall be integrated and developed by Licensor as a medical product according to applicable local medical product regulations including, but not limited to the EU and the USA, integrating and combining the Software, MR System, Catheter Technology and Peripheral Technology. The summary describes the components and operation of an MRI-guided EP ablation system. The system uses active (signal receiving) invasive devices and special software for customized image reconstruction and display. In the prototyping phase, the software component of the system will run on a computer attached to the scanner, while for the product version, the software component of the system will run on the scanners host computer.

MR System shall mean any applicable Licensee MR system. Target MR System for the Product include the Magnetom Verio and the Magnetom Espree. Other MR System might be added after mutual agreement. The MR System is currently provided by Licensee as a medical product according to applicable local medical product regulations in several countries, including, but not limited to, the EU, Canada and the USA.

Software means software and dedicated MR sequences, which are developed by Licensee according to requirement specifications by Licensor. These specifications are defined in the Agreement. For the avoidance of doubt, Software does not include the base modules IFE and IRTTT, or any further developments or future versions of IFE or IRTTT, but only the dedicated plug in module dedicated to the workflow of the Product developed under this Agreement.

Background Patents shall mean patent applications, patents, utility models and other statutory protection with regard to MR System, Application, Catheter Technology, Peripheral Technology, Software, Integration or the Product under which one PARTY is the owner and/or has the right of determination at any time during the term of this Agreement and which are not a Development Result.

Catheter Technology shall mean and comprise the invasive medical devices (e.g. guidewire, catheters) supplied by Licensor for the use in the Product and within and in close proximity to an MR System and which are defined in this Agreement. The Catheter Technology shall be provided by Licensor as a medical product according to applicable local medical product regulations including, but not limited to, the EU and the USA.

Peripheral Technology means hardware and software required by the user to perform the Application with the Product and which is not already included in Catheter Technology or Software or MR System.

Application shall mean the treatment of cardiac arrhythmia by catheter mediated ablation under simultaneous MR imaging and catheter mediated cardiac electrophysiological mapping under simultaneous MR imaging by using the Product. In the event the width of an Application is specified through guidelines of regulatory bodies like SFDA, CE, FDA, such specification shall apply.

Field of Use
Licensee is a leading company in developing, manufacturing and selling Magnetic Resonance (“MR”) Imaging systems, which are used worldwide for diagnostics of a wide variety of medical indications. MR imaging is free of ionizing radiation and is therefore well-suited for continued supervision of treatment procedures.

The Parties wish to establish a Cooperation and Development Agreement aiming at a combination of the capabilities of Catheter Ablation and MR imaging in developing a product combination that allows performing the treatment of cardiac arrhythmias by catheter mediated ablation and catheter mediated cardiac electrophysiological mapping procedure under simultaneous MR imaging for worldwide marketing and sales.  The Parties agree that this treatment consists of a procedure with the involvement of different medical devices, including catheters and mapping technology as well as MR imaging guidance. The Parties intend to develop an MR workflow with all required components integrated into the special requirements of the MR environment.

Field shall mean treatment of cardiac arrhythmia by catheter mediated ablation under simultaneous MR imaging and catheter mediated cardiac electrophysiological mapping under simultaneous MR imaging.

IPSCIO Record ID: 26864

License Grant
University is willing to grant a worldwide, exclusive license in the defined FIELD OF USE to Licensee.  The University is the owner and that it has the right to exclusively license those inventions which are the subject matter of USC File No. 2651 entitled 'Balloon Protection Guide Wire Device For Carotid Balloon Angioplasty and Stenting' and USC Pile 2639 entitled 'New Balloon-Inflated Carotid Artery Stent to Assist in Carotid Artery Balloon Angioplasty'.
License Property
Guardian Embolization Protection System patented technology with primary use in the neurointerventional and cardiology markets these markets focus on arteries and veins leading to the brain and those in the heart, and the removal of blockages in these veins and arteries.  The device is designed to prevent deadly embolisms during surgery to clear blocked arteries and prevent strokes and heart attacks.  The key to this device, known as the Guardian System, is a thin string of wire, really a metal tube not much larger in diameter than a human hair, with a marble-sized balloon attached toward the end.

USC File 2651 U.S. Patent Application Serial No. 08/767,221 filed December 16, 1996 (abandoned) entitled 'Cerebral Protection Balloon For Use In Carotid Artery Angioplasty and Stenting'

USC File 2561 U.S. Patent Application Serial No. 08/906,890 filed August 6,1997 (which is a continuation of U.S. Ser. No. 08/767,221), entitled Angioplasty Catheter'.

USC File 2561 PCT Patent Application Serial No. PCT/US97/23257 filed December16, 1997 and corresponding to U.S. Patent Applications Serial Nos. 08/767,221and 08/906,890.

USC File 2639 Invention Disclosure entitled 'New Balloon-Inflated Carotid Artery Stent to Assist in Carotid Artery Balloon Angioplasty'.

Field of Use
'FIELD OF USE' shall mean diagnostic and/or therapeutic devices to be used in the treatment or management of patients via the carotid artery or other arteries or veins.

IPSCIO Record ID: 1850

License Grant
The Company entered into an agreement for the license for Epidural catheters used to infuse drugs into the epidural space in the spinal column (vi) Implantable infusion ports and pumps and their attached catheters used for drug therapy and access to the vascular system (vii) Intra-aortic balloon catheters (viii) Drainage catheters used to drain chest cavities, surgical incisions, wounds and abscesses.
Field of Use
Fields of Application)
(v) Epidural catheters used to infuse drugs into the epidural space in the spinal column.
(vi) Implantable infusion ports and pumps and their attached catheters used for drug therapy and access to the vascular system.
(vii) Intra-aortic balloon catheters.
(viii) Drainage catheters used to drain chest cavities, surgical incisions, wounds and abscesses.

IPSCIO Record ID: 204314

License Grant
Licensor grants a worldwide, exclusive license to use and sell X-Ray Systems in the Field.  Licensee desires to be the exclusive marketing and distribution entity for X-Ray Systems.
License Property
The Parties will co-develop and co-manufacture a disposable miniature x-ray source, based on the X-SEED and associated technology, for the delivery of intravascular radiation therapy to prevent restenosis (re-narrowing) of coronary arteries following angioplasty and stent procedures.  The new system will include an integrated disposable x-ray tube and catheter and a delivery and control device to deliver intravascular radiation therapy. Both companies will manufacture components for the system, which will be co-labeled.

Pursuant to this agreement, each party will have the licensed rights to use the X-Ray System or components.  The parties have agreed to develop certain X-Ray Systems which incorporate and combine Catheter Body Subassemblies and Delivery Devices developed and manufactured by Licensee with X-Ray Tubes and Control Devices developed and manufactured by Licensor.

X-Seed is a prototype of a new system for delivering x-rays from inside blood vessels following an operation for clogged arteries.

Based on a concept of the Licensor's patented and patent-pending technology, the x-ray source uses a combination of lasers, fiber optics and high voltages to produce x-rays. The X-Seed miniature x-ray system is completely self-contained, and its key components are less than one millimeter in diameter. X-Seed is designed to be placed at the end of a fine, flexible catheter, which will then be inserted inside blood vessels to deliver a dose of radiation to the interior surface.

The overall components of the system are  Catheter Body Subassembly,  X-Ray Tube, Control Device and Delivery Device.

Field of Use
The Field shall mean the field of Intravascular Radiotherapy.

Intravascular Radiotherapy is a radiation therapy system that helps prevent the repeated narrowing of coronary arteries that have already undergone the procedure of stenting.

IPSCIO Record ID: 308743

License Grant
Licensor grants to Licensee a worldwide, exclusive license to make, have made, use and sell Royalty Products.
License Property
Royalty Product means any Lead Extractor covered by a claim of an unexpired patent in the Licensed Intellectual Property or employing Licensor Confidential Information in the Licensed Intellectual Property; provided that the laser generators and other capital equipment of Licensee will not be considered Royalty Product. Lead Extractors sold for the purpose of clinical trials required for obtaining government approval to market in any country shall not be deemed Royalty Product.

Lead Extractor means a device for aiding in removal of medical devices such as pacing and defibrillation leads or catheters.

Licensed Intellectual Property means (1) All U.S. patents and patent applications owned by or licensed to, with the right to sublicense, Licensor which are now or during the term of this Agreement developed for use in the laser extraction of leads or catheters, including U.S. Patent 5,423,806 entitled 'Laser Extractor for an Implanted Object' and U.S. Patent Application 08/153,715 entitled 'Heart Synchronized Extractor for an Implanted Object'; (2) all patent rights derived from such patents and patent applications, including but not limited to foreign rights, divisionals, continuations, continuations in part, re-issues, and reexaminations; and (3) any confidential information provided to Licensee by Licensor (a) under the terms of the Agreement for Mutual Exchange of Confidential Information between Licensee and Licensor dated May 21, 1991 (the Confidentiality Agreement), (b) in written form and marked as proprietary, confidential or the like, before and during the development of Licensee products, including but not limited to the original concept drawings and information disclosures (collectively the Licensor Confidential Information).  Licensor Confidential Information shall not, however, include information which
    (i)   is or was known to Licensee prior to receipt thereof under this Agreement or the Confidentiality Agreement, as evidenced by written records;
    (ii)  is disclosed without restriction to Licensee in good faith by a third party who is in lawful possession thereof and who has the right to make such disclosure;
    (iii) is or shall have become public knowledge, by publication or otherwise, through no fault of Licensee;  
    (iv)  is discovered by Licensee completely without reference to Licensor Confidential Information; or
    (v)   is transmitted to Licensee by Licensor after Licensor received notification in writing from Licensee that Licensee did not desire to receive any further Licensor Confidential information.

U.S. Patent 5,423,806 entitled Laser Extractor for an Implanted Object
U.S. Patent Application 08/153,715 entitled Heart Synchronized Extractor for an Implanted Object

Licensor has developed technology relating to laser lead extraction and owns intellectual property related thereto.

Field of Use
The field of use is in the medical industry relating to devices for aiding in removal of medical devices such as pacing and defibrillation leads or catheters.

Licensee develops, manufactures, markets, and distributes its technology for interventional cardiovascular therapy. The Companys system is used in applications such as coronary angioplasty and the removal of pacemaker leads.

IPSCIO Record ID: 1710

License Grant
The Company hereby grants an exclusive, worldwide right and license, including the right to grant sublicenses, under the Technical Know-How, Licensed Patents and Improvements to practice methods and to manufacture, have manufactured, import, use, offer to sell, sell and otherwise dispose of Licensed Products within the Field of Technology; technology applications relating to the use of lasers to treat cardiovascular or vascular disease.
License Property
Licensed Products shall mean Patented Licensed Products and Unpatented Licensed Products and shall include single use, disposable products as well as the related laser hardware.

Transmyocardial laser revascularization (TMLR) has emerged as a promising therapy for patients with end-stage coronary artery disease not amenable to other forms of therapy. TMLR is a surgical technique typically performed through a left thoracotomy, which uses a laser to bore 15 to 30 transmural channels from the epicardial to the endocardial surfaces through the left ventricular myocardium of the beating heart in an attempt to improve local perfusion to ischemic myocardial territories not being reached by diseased arteries.

Field of Use
Field of Technology  shall mean the use of lasers to treat cardiovascular or vascular disease.

IPSCIO Record ID: 3990

License Grant
The Foundation owns the Licensable Technology as defined. The Optionee specializes in developing technology and bringing new technologies to market; and desires to investigate and conduct due diligence with respect to the commercial viability of the Licensable Technology prior to executing the License Agreement.
License Property
'Licensable Patents' shall refer to and mean US Patent Application # 60/797,433 entitled 'Intra-jugular Catheter' and any U.S. or foreign patent applications, reissues, extensions, renewals, reexaminations, certificates of invention, substitutions, divisions, continuations, and continuations-in-part thereof having the Principal Investigator as an inventor and having the same priority date as the parent applications. The Field shall mean clinical use as a catheter for insertion into the vascular system of a patient to direct fluid flow, sampling of fluids and oxygenation monitoring.
Field of Use
'Field' shall mean clinical use as a catheter for insertion into the vascular system of a patient to direct fluid flow, sampling of fluids and oxygenation monitoring.

IPSCIO Record ID: 215206

License Grant
Licensor grants a worldwide right and license to manufacture and sell X-Ray Systems exclusively to Licensor for use in the Field.

Licensor grants a worldwide, non-exclusive license to manufacture, use and sell Delivery Devices outside the Field.

Pursuant to this agreement, each party will have the licensed rights to use the X-Ray System or components.  The parties have agreed to develop certain X-Ray Systems which incorporate and combine Catheter Body Subassemblies and Delivery Devices developed and manufactured by Licensee with X-Ray Tubes and Control Devices developed and manufactured by Licensor.

License Property
The Parties will co-develop and co-manufacture a disposable miniature x-ray source, based on the X-SEED and associated technology, for the delivery of intravascular radiation therapy to prevent restenosis (re-narrowing) of coronary arteries following angioplasty and stent procedures.  The new system will include an integrated disposable x-ray tube and catheter and a delivery and control device to deliver intravascular radiation therapy. Both companies will manufacture components for the system, which will be co-labeled.

Pursuant to this agreement, each party will have the licensed rights to use the X-Ray System or components.  The parties have agreed to develop certain X-Ray Systems which incorporate and combine Catheter Body Subassemblies and Delivery Devices developed and manufactured by Licensee with X-Ray Tubes and Control Devices developed and manufactured by Licensor.

X-Seed is a prototype of a new system for delivering x-rays from inside blood vessels following an operation for clogged arteries.

Based on a concept of the Licensor's patented and patent-pending technology, the x-ray source uses a combination of lasers, fiber optics and high voltages to produce x-rays. The X-Seed miniature x-ray system is completely self-contained, and its key components are less than one millimeter in diameter. X-Seed is designed to be placed at the end of a fine, flexible catheter, which will then be inserted inside blood vessels to deliver a dose of radiation to the interior surface.

The overall components of the system are  Catheter Body Subassembly,  X-Ray Tube, Control Device and Delivery Device.

Field of Use
The Field shall mean the field of Intravascular Radiotherapy.

Intravascular Radiotherapy is a radiation therapy system that helps prevent the repeated narrowing of coronary arteries that have already undergone the procedure of stenting.

Licensee is leveraging its core expertise in miniature x-ray technology into distinct markets including cancer treatment, intravascular care, industrial x-ray, and radiation dosimetry products.

IPSCIO Record ID: 2663

License Grant
Seller, an individual, hereby sells, assigns, transfers and conveys to Purchaser all right, title and interest it has in and to the Patents and all inventions and discoveries described therein, including without limitation, all rights of Seller under the Assignment Agreement, and all rights of Seller to collect royalties under such Patents.
License Property
The Licensor (Seller) wishes to sell to the Licensee (Purchaser) all right, title and interest in the Patents 5,476,450. Apparatus and Method for Aspirating Intravascular, Pulmonary and Cardiac Obstructions.

IPSCIO Record ID: 27532

License Grant
The parties desire to amend the Agreement in order to modify their arrangements with respect to the development of the X-Ray Systems.
License Property
X-Ray Systems is based on Photoelectron's patented technology. The new system will include an integrated disposable x-ray tube and catheter and a delivery and control device to deliver intravascular radiation therapy.

Licensor is leveraging its core expertise in miniature x-ray technology into distinct markets including cancer treatment, intravascular care, industrial x-ray, and radiation dosimetry products.

The Parties will co-develop and co-manufacture a disposable miniature x-ray source, based on the X-SEED and associated technology, for the delivery of intravascular radiation therapy to prevent restenosis (re-narrowing) of coronary arteries following angioplasty and stent procedures.  The new system will include an integrated disposable x-ray tube and catheter and a delivery and control device to deliver intravascular radiation therapy. Both companies will manufacture components for the system, which will be co-labeled.

Pursuant to this agreement, each party will have the licensed rights to use the X-Ray System or components.  The parties have agreed to develop certain X-Ray Systems which incorporate and combine Catheter Body Subassemblies and Delivery Devices developed and manufactured by Licensee with X-Ray Tubes and Control Devices developed and manufactured by Licensor.

X-Seed is a prototype of a new system for delivering x-rays from inside blood vessels following an operation for clogged arteries.

Based on a concept of the Licensor's patented and patent-pending technology, the x-ray source uses a combination of lasers, fiber optics and high voltages to produce x-rays. The X-Seed miniature x-ray system is completely self-contained, and its key components are less than one millimeter in diameter. X-Seed is designed to be placed at the end of a fine, flexible catheter, which will then be inserted inside blood vessels to deliver a dose of radiation to the interior surface.

Field of Use
The Field shall mean the field of Intravascular Radiotherapy.

Intravascular Radiotherapy is a radiation therapy system that helps prevent the repeated narrowing of coronary arteries that have already undergone the procedure of stenting.

IPSCIO Record ID: 27674

License Grant
The Licensor hereby grants to the Company and its Affiliates an exclusive, worldwide right under the Patent Rights and Related Materials in the Company's Field of Use to (i) design, develop, make, have made, use, sell, offer for sale, import, export or otherwise distribute products in the Company's Field of Use, and (ii) practice or authorize the practice of any method, process, or procedure in the Company's Field of Use.
License Property
Patents relate to applying radiofrequency energy to tissue.

United States Patent No. 5,057,105

United States Patent No. RE 35,330

Australian Patent No.  633358

Canadian Patent No. 2,065,261

European Regional Patent No. 489,814 (in effect in Germany, France, Great Britain, Italy)

Field of Use
The Company's Field of Use shall mean the Gastro-Intestinal Tract in the medical industry.

IPSCIO Record ID: 213765

License Grant
The parties entered into an agreement to acquire the intellectual property rights associated with a steerable guidewire system.
License Property
Steerable guidewire system – devices used in angioplasty and stent placement; diagnostic and therapeutic catheters used for various procedures in cardiology and radiology.
Field of Use
This agreement pertains to the medical industry.

IPSCIO Record ID: 1941

License Grant
The Company has agreed to pay doctors' efforts in connection with the laser catheter ablation system.
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