Royalty Report: Scientific & Technical Instruments, Test/Monitoring, Drugs – Collection: 152

'LICENSED PRODUCT' shall mean any scattered-radiation-based product used to detect or classify microorganisms in water (including, without limitation, JMAR's BioSentry product and successors and replacements thereof) or any product that falls within the scope of, or utilizes any method or process which falls within the scope of, any of the claims of the licensed patents, or that incorporates, or is itself, the subject invention of any of the licensed patents, now or hereafter made or used, imported, leased, sold or otherwise disposed of, by or on behalf of JMAR (including any finished product and any finished product used in the manufacture of another product).

        TITLE                PATENT NO.          

'Identification of Particles in Fluid'       6,774,995
'Identification of Particles in Fluid'       6,519,033
'Particle Detection Beam'                    6,628,386
'Plano Convex Fluid Carrier For Scattering Correction' (Fluid  Carrier For Scatter Detection)                             6,573,992

'Flow Through LightScattering Device'        6,590,652                                  
'High Detection Rate Particle Identifier'       10/412,100  
'Unsupervised Learning  Detect New Class In Field'       6,819,421                                  
'Optical Sensor Module Tester'        10/394,986
'Particulate Info To Field Units'         10/393,459
'Holographic Spherical  Lenses'          6,760,107
'Solubilizer/Dispersant For Insoluble Organics That Is Harmless For  Bacteria'     60/572,937
'Automatic Adaption Of  Background Signature'      60/602,612
'Particle ID With  Narrow Angle Detectors'     10/834,516

CORTS (BioSentry) system is used for the detection of microorganisms in water.

Universal Gas Sensor Patent Application Filed Non-provisional United States patent application entitled A Universal Gas Sensor for the Selective Detection of Toxic Chemicals and Combustable Gases

The Licensee's sensors are used for detection of hydrogen, the most plentiful element on the earth. Hydrogen is one of two major elements of water, which covers over 60% of the planet.

Cryptosporidium is an intestinal parasite that can live in the digestive tracts of humans and livestock.  It has been found in over 95% of all surface waters that have been tested worldwide.  These organisms are transmitted by drinking infected water and can cause gastrointestinal illnesses of varying severity.

Licensor grants the nonexclusive worldwide right and license, under the Licensed Patents and Licensor Technical Information, to manufacture, have made, use, develop, sell, and have sold Licensed Products within the Military Field in the Territory during the Agreement Term.

Amplification/Detection Technology means Licensors technologies for facilitating the process of chemically multiplying the numbers of target sequences of DNA or RNA in order to facilitate their identification or detection using fluorescent labels or similar approaches.

Applicable Cepheid technologies include, but are not limited to I-CORE Modules, reaction tubes, and proprietary Reagents.

Fluidics/Lysing Technology means Licensors technologies for fluid handling and processing as applied to the preparation of samples for DNA or RNA based analysis, including filtration, lysing of cells or cellular organisms, capture and purification of DNA or RNA, mixing of sample with Reagents, and delivery to a reaction tube or chamber.

Hand-Held System means an integrated system for detection of DNA or RNA sequences that employs PCR or other thermally controlled nucleic acid amplification methods; contains between one and eight reaction sites; carries out the processes of amplification, detection, analysis, reporting, and user interface all in one case or housing; is capable of operating on battery power; and may or may not employ fluidic sample preparation cartridges that are designed for integrated use with the system.

I-CORE Module means a Licensor proprietary nucleic acid amplification Module comprised of a single site, discrete, individually controllable heater sleeve containing a heater element and designed to accept a disposable reaction tube or cartridge, an integrated cooling mechanism, such as a fan, that enables passage of ambient or cooled air across the heater sleeve, and optical blocks containing solid state components that enable optical interrogation of the reaction solution in the reaction tube or cartridge, as it may be modified and improved from time to time.

Integrated Military Bioagent Detection System means a system comprised of distinct component parts, each capable of carrying out a specific phase of a complete field-based, non-laboratory-based analysis for the presence of Bioagents, with component parts that include, but are not limited to, sample collection (usually air samples) component, nucleic acid-based analysis component (identifier), and reporter/data transmitter component.

Patents relate to Amplification/Detection Technology, and, Fluidics and/or Lysing Technology.

The Licensed Fields means the DP Field and the Military Field.  DP Field in this Agreement, means Hand Held Systems for the domestic preparedness and military markets.  Military Field means Integrated Military Bioagent Detection Systems for use by governmental military customers only for the detection of Bioagents, excluding Hand-Held Systems.

“Patents” means any and all patent applications (including any amendments or extensions to the initial applications) filed in any country of the world by or on behalf of MSU claiming the Technology and/or any patents maturing from such patent applications. Patents and patent applications claiming the technology at the time of execution of this Agreement include, without limitation, United States provisional patent application 60/704,550 titled “Nanoporous Silicon-Based Electrochemical DNA Biosensor”, filed August 2, 2005.